benzyl tert-butyl iMidodicarboxylate

Base Information

• Chemical Name: benzyl tert-butyl iMidodicarboxylate
• CAS No.: 120542-13-4
• Molecular Formula: C13H18N2O2
• Molecular Weight: 251.282
• Mol file: 120542-13-4.mol

Synonyms:benzyl tert-butyl iMidodicarboxylate

Chemical Property of benzyl tert-butyl iMidodicarboxylate

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl tert-butyl iMidodicarboxylate

There total 8 articles about benzyl tert-butyl iMidodicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

benzyl N-[(tert-butoxy)carbonyl]-N-(4-methoxybenzyl)carbamate → benzyl N-[(tert-butoxy)carbonyl]carbamate (120542-13-4)

Guidance literature:

With ammonium cerium (IV) nitrate; In water; acetonitrile; at 20 ℃;

DOI:10.1002/chem.201602792

Reference yield:

Benzyl N-hydroxycarbamate (3426-71-9) + di-tert-butyl dicarbonate (24424-99-5) → benzyl N-[(tert-butoxy)carbonyl]carbamate (120542-13-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1039/c6ob00891g

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → benzyl N-[(tert-butoxy)carbonyl]carbamate (120542-13-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; hydroxylamine hydrochloride / water; dichloromethane / 20 °C

2: sodium hydroxide / tetrahydrofuran; water / 20 °C

With hydroxylamine hydrochloride; sodium hydrogencarbonate; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1039/c6ob00891g

upstream raw materials:

benzyloxycarbonyl isocyanate

tert-butyl alcohol

O-benzyl carbamate

N-(benzyloxycarbonyl)benzamide

Downstream raw materials:

(R)-Z(Boc)-Ala-OEt

N¹,N²-dibenzyloxycarbonyl-N²-tert-butoxycarbonyl-N¹-ethyl-1,2-ethylenediamine

sodium benzyl tert-butyl iminodicarbonate

C₁₃H₁₆NO₄^(1-)*K⁽¹⁺⁾