6-Isopropylnicotinic acid hydrochloride

Base Information

• Chemical Name: 6-Isopropylnicotinic acid hydrochloride
• CAS No.: 1423029-80-4
• Molecular Formula: C9H12ClNO2
• Molecular Weight: 201.65008
• Mol file: 1423029-80-4.mol

Synonyms:6-Isopropylnicotinic acid hydrochloride

Chemical Property of 6-Isopropylnicotinic acid hydrochloride

Chemical Property:

• PSA: 50.19000
• LogP: 2.70520

Purity/Quality:

99% ^*data from raw suppliers

6-IsopropylnicotinicAcidHydrochloricAcidSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Isopropylnicotinic acid hydrochloride

There total 3 articles about 6-Isopropylnicotinic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl 6-isopropylnicotinate (84625-02-5) → 6-isopropylnicotinic acid hydrochloride (1423029-80-4)

Guidance literature:

With hydrogenchloride; In water; at 80 ℃; for 16h;

DOI:10.1021/jm4014696

Reference yield:

methyl 6-bromonicotinate (26218-78-0) → 6-isopropylnicotinic acid hydrochloride (1423029-80-4)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / water; 1,4-dioxane / 6 h / 80 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 18 h / 20 °C / 3750.38 Torr / Inert atmosphere

3: hydrogenchloride / water / 16 h / 80 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium carbonate; triphenylphosphine; In 1,4-dioxane; methanol; water; 1: |Suzuki Coupling;

DOI:10.1021/jm4014696

Reference yield:

methyl 6-(prop-1-en-2-yl)nicotinate (1610768-08-5) → 6-isopropylnicotinic acid hydrochloride (1423029-80-4)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 18 h / 20 °C / 3750.38 Torr / Inert atmosphere

2: hydrogenchloride / water / 16 h / 80 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water;

DOI:10.1021/jm4014696

upstream raw materials:

methyl 6-bromonicotinate

methyl 6-(prop-1-en-2-yl)nicotinate

methyl 6-isopropylnicotinate

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