2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethanamine

Base Information

• Chemical Name: 2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethanamine
• CAS No.: 40255-48-9
• Molecular Formula: C13H21N3O
• Molecular Weight: 235.329
• Hs Code.: 2933599090
• DSSTox Substance ID: DTXSID40439294
• Wikidata: Q82255212
• Mol file: 40255-48-9.mol

Synonyms:40255-48-9;2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethanamine;2-[4-(2-methoxyphenyl)piperazin-1-yl]ethanamine;2-[4-(2-methoxyphenyl)piperazin-1-yl]ethan-1-amine;1-(2-aminoethyl)-4-(2-methoxyphenyl)piperazine;SCHEMBL4404160;DTXSID40439294;NDVVQPVEUGLAPX-UHFFFAOYSA-N;MFCD00920301;AKOS000191611;AS-30256;[4-(2-methoxyphenyl)piperazino]ethylamine;CS-0215349;FT-0762636;EN300-236013;4-(2-aminoethyl)-1-(2-methoxyphenyl)pyperazine;1-(2-aminoethyl)-4-(2-methoxyphenyl)-piperazine;2-(4-(2-methoxyphenyl)piperazin-1-yl)ethylamine;2-[4-(2-methoxyphenyl)-piperazin-1-yl]-ethylamine;4-[(2-amino) ethyl]-1-(2-methoxyphenyl)piperazine;4-[(2-amino)ethyl]-1-(2-methoxyphenyl)piperazine;F2158-0049

Chemical Property of 2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethanamine

Chemical Property:

• Melting Point: 76-77 °C(Solv: methanol (67-56-1))
• Boiling Point: 375.8±42.0 °C(Predicted)
• PKA: 10.11±0.10(Predicted)
• PSA: 41.73000
• Density: 1.079±0.06 g/cm3(Predicted)
• LogP: 1.47910
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 235.168462302
• Heavy Atom Count: 17
• Complexity: 217

Purity/Quality:

99% ^*data from raw suppliers

2-(4-(2-METHOXYPHENYL)PIPERAZIN-1-YL)ETHANAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1N2CCN(CC2)CCN

Technology Process of 2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethanamine

There total 11 articles about 2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]phthalimide (99718-67-9) → 1-(2-aminoethyl)-4-(2-methoxyphenyl)piperazine (40255-48-9)

Guidance literature:

With hydrazine; In ethanol; water; at 20 ℃; for 18h;

Reference yield: 99.0%

[4-(2-methoxyphenyl)piperazin-1-yl]acetonitrile (92043-13-5) → 1-(2-aminoethyl)-4-(2-methoxyphenyl)piperazine (40255-48-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 12h; Inert atmosphere; Reflux;

DOI:10.1016/j.ejmech.2014.07.096

Reference yield: 98.0%

1-(2-azidoethyl)-4-(2-methoxyphenyl)piperazine (600709-61-3) → 1-(2-aminoethyl)-4-(2-methoxyphenyl)piperazine (40255-48-9)

Guidance literature:

With 1.3-propanedithiol; triethylamine; In methanol; at 20 ℃; for 72h;

DOI:10.1021/jm0211220

upstream raw materials:

[4-(2-methoxyphenyl)piperazin-1-yl]acetonitrile

1-(2-azidoethyl)-4-(2-methoxyphenyl)piperazine

N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]phthalimide

1-(2-Methoxyphenyl)piperazine

Downstream raw materials:

3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione

4-(3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-ureido)-furan-3-carboxylic acid

4-(3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-ureido)-2,5-dimethyl-furan-3-carboxylic acid