ACHN 490

Base Information

Chemical Name:ACHN 490
CAS No.:1154757-24-0
Molecular Formula:C25H48N6O10
Molecular Weight:592.69
Hs Code.:
Mol file:1154757-24-0.mol

Synonyms:ACHN 490;O-2-AMino-2,3,4,6-tetradeoxy-6-[(2-hydroxyethyl)aMino]-α-D-glycero-hex-4-enopyranosyl-(1→4)-O-[3-deoxy-4-C-Methyl-3-(MethylaMino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-4-aMino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptaMine;PlazoMicin

Suppliers and Price of ACHN 490

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
Plazomicin
25 mg
$ 13500.00

Total 17 raw suppliers

Chemical Property of ACHN 490

Chemical Property:

Boiling Point:896.4±65.0 °C(Predicted)
PKA:13.11±0.20(Predicted)
PSA：272.78000
Density:1.40±0.1 g/cm3(Predicted)
LogP:-1.63810
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Water (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Plazomicin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Plazomicin is a neoglycoside antibiotic with activity against a broad range of Gram-positive and Gram-negive pathogens. Plazomicin showed potent in vitro activity against multidrug-resistant Klebsiella pneumoniae and Escherichia coli.

Technology Process of ACHN 490

There total 11 articles about ACHN 490 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1154758-74-3
6'-tert-butyldimethylsiloxyethyl-2',3,3-tri-(tert-butoxycarbonyl)-1-[N-tert-butoxycarbonyl-4-amino-2(S )-hydroxybutyryl]sisomicin

: 1154757-24-0
ACHN-490

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 35 ℃; for 2h;

Reference yield:

: plazomicin phosphate

: 1154757-24-0
ACHN-490

Guidance literature:: With anion exchange resin; In methanol; for 10h; Inert atmosphere; Green chemistry;

Reference yield:

: 1154758-63-0
tert-butyl ((2R,3R,4R,5R)-2-(((1S,2S,3R,4S,6R)-3-(((2S,3R)-6-(aminomethyl)-3-((tert-butoxycarbonyl)amino)-3,4-dihydro-2H-pyran-2-yl)oxy)-4-((tert-butoxycarbonyl)amino)-6-((S)-4-((tert-butoxycarbonyl)amino)-2-hydroxybutanamido)-2-hydroxycyclohexyl)oxy)-3,5-dihydroxy-5-methyltetrahydro-2H-pyran-4-yl)(methyl)carbamate

: 1154757-24-0
ACHN-490

Guidance literature:: Multi-step reaction with 2 steps

1: silica supported cyanoborohydride / methanol / 0.25 h / 100 °C / Microwave irradiation

2: trifluoroacetic acid / dichloromethane / 0.75 h / 0 °C

With trifluoroacetic acid; In methanol; dichloromethane;