PFI-4

Base Information

• Chemical Name: PFI-4
• CAS No.: 900305-37-5
• Molecular Formula: C21H24N4O3
• Molecular Weight: 380.44
• Mol file: 900305-37-5.mol

Synonyms:PFI-4

Chemical Property of PFI-4

Chemical Property:

• Boiling Point: 512.1±50.0 °C(Predicted)
• PKA: 12.88±0.20(Predicted)
• PSA: 68.50000
• Density: 1.291±0.06 g/cm3(Predicted)
• LogP: 2.87610
• Storage Temp.: room temp
• Solubility.: insoluble in H2O; ≥13.3 mg/mL in DMSO; ≥2.87 mg/mL in EtOH with gentle warming and ultrasonic

Purity/Quality:

97% ^*data from raw suppliers

PFI4 ≥99%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: PFI 4 is an SGC chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) scaffolding protein BRPF1B. PFI 4 specifically binds to BRPF1B with an IC50 = 172 nM and Kd =13 nM as determined by ITC. PFI 4 reduces recovery time in triple BRD cell construct in FRAP and is potent in cells with IC50 250nM, while showing no effect on BRPF1A. PFI 4 exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4.
• Uses: PFI-4 is a chemical probe that specifically binds to the bromodomain of BRPF1 inhibiting binding to tri-acetylated histone 4 affecting the development of multiple tissues axial skeleton and hematopoietic system.