Technology Process of 4-chloro-6-cyclopropylpyrimidine(SALTDATA: FREE)
There total 2 articles about 4-chloro-6-cyclopropylpyrimidine(SALTDATA: FREE) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
caesium carbonate; catacxium A;
palladium diacetate;
In
toluene;
at 100 ℃;
for 24h;
Inert atmosphere;
Microwave irradiation;
- Guidance literature:
-
4-Hydroxyderivat II, POCl3;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium carbonate / 1,4-dioxane / 0.67 h / 130 °C / Microwave irradiation
2: bromine / ethanol / 18 h / -10 - 20 °C
3: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; ethanol; 1,2-dimethoxyethane; water / 0.33 h / 90 °C / Microwave irradiation
4: potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 18 h / 100 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); bromine; potassium acetate; sodium carbonate;
In
1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; toluene;
4: |Suzuki Coupling;
DOI:10.1021/acsmedchemlett.0c00575
