4-methyl-2-[(2-thienylcarbonyl)amino]-5-Thiazolecarboxylic acid ethyl ester

Base Information

• Chemical Name: 4-methyl-2-[(2-thienylcarbonyl)amino]-5-Thiazolecarboxylic acid ethyl ester
• CAS No.: 330978-57-9
• Molecular Weight: 296.37
• Mol file: 330978-57-9.mol

Synonyms:4-methyl-2-[(2-thienylcarbonyl)amino]-5-Thiazolecarboxylic acid ethyl ester

Chemical Property of 4-methyl-2-[(2-thienylcarbonyl)amino]-5-Thiazolecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-methyl-2-[(2-thienylcarbonyl)amino]-5-Thiazolecarboxylic acid ethyl ester

There total 4 articles about 4-methyl-2-[(2-thienylcarbonyl)amino]-5-Thiazolecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-Thiophenecarbonyl chloride (5271-67-0) + ethyl-2-amino-4-methylthiazole-5-carboxylate (7210-76-6) → ethyl 4?methyl?2?(thiophene?2?carboxamido)thiazole?5?carboxylate (330978-57-9)

Guidance literature:

With pyridine; at 0 - 5 ℃; for 0.166667h;

DOI:10.1007/s10870-019-00800-w

Reference yield:

ethyl acetoacetate (141-97-9) → ethyl 4?methyl?2?(thiophene?2?carboxamido)thiazole?5?carboxylate (330978-57-9)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide / tetrahydrofuran; water

2: 80 °C

3: pyridine / 0.17 h / 0 - 5 °C

With pyridine; N-Bromosuccinimide; In tetrahydrofuran; water;

DOI:10.1007/s10870-019-00800-w

Reference yield:

ethyl 2-bromoacetoacetate (84911-18-2,609-13-2) → ethyl 4?methyl?2?(thiophene?2?carboxamido)thiazole?5?carboxylate (330978-57-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 °C

2: pyridine / 0.17 h / 0 - 5 °C

With pyridine;

DOI:10.1007/s10870-019-00800-w

upstream raw materials:

2-Thiophenecarbonyl chloride

ethyl-2-amino-4-methylthiazole-5-carboxylate

ethyl acetoacetate

ethyl 2-bromoacetoacetate