ReModelin

Base Information

Chemical Name:ReModelin
CAS No.:949912-58-7
Molecular Formula:C₁₅H₁₄N₄S
Molecular Weight:282.369
Hs Code.:
Mol file:949912-58-7.mol

Synonyms:ReModelin;4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile hydrobromide;4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile

Suppliers and Price of ReModelin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Remodelin
50mg
$ 545.00

Tocris
Remodelin ≥99%(HPLC)
10
$ 168.00

Tocris
Remodelin ≥99%(HPLC)
50
$ 693.00

Sigma-Aldrich
Remodelin hydrobromide ≥98% (HPLC)
5mg
$ 106.00

Sigma-Aldrich
Remodelin hydrobromide ≥98% (HPLC)
25mg
$ 416.00

DC Chemicals
Remodelin >98%
100 mg
$ 400.00

Crysdot
Remodelin 98+%
10mg
$ 94.00

Crysdot
Remodelin 98+%
5mg
$ 52.00

Crysdot
Remodelin 98+%
50mg
$ 395.00

Chemenu
4-(2-(2-cyclopentylidenehydrazinyl)thiazol-4-yl)benzonitrile 98%
50mg
$ 373.00

Total 12 raw suppliers

Chemical Property of ReModelin

Chemical Property:

Boiling Point:498.9±47.0 °C (760 mmHg)
PSA：89.31000
Density:1.31±0.1 g/cm3 (20 °C, 760 mmHg)
LogP:4.09668
Storage Temp.:2-8°C
Solubility.:DMSO: soluble20mg/mL, clear

Purity/Quality:

99%, ^*data from raw suppliers

Remodelin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Description Progeria is a genetic disorder that results in the appearance of premature aging. Genetically, progeria is characterized by a mutation in lamin A, which results in misshapen cell nuclei and DNA damage. Remodelin is a 2-thiazolylhydrazone derivative that, at 10 μM, improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria. Remodelin is an inhibitor of N-acetyltransferase 10 (NAT10), which acetylates both histones and microtubules. Mutation of NAT10 mimics the effects of remodelin on nuclear morphology, suggesting that these effects of remodelin require NAT10. Remodelin also has cytotoxic effects against some species of the fungus Candida.
Uses Remodelin improves nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and Hutchinson-Gilford progeria syndrome (HGPS)-derived patient cells. N-acetyltransferase 10 (NAT10) inhibitor.

Technology Process of ReModelin

There total 1 articles about ReModelin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: