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Technology Process of N-(2-aminophenyl)pyrazine-2-carboxamide

N-(2-aminophenyl)pyrazine-2-carboxamide

Base Information
  • Chemical Name:N-(2-aminophenyl)pyrazine-2-carboxamide
  • CAS No.:926259-99-6
  • Molecular Formula:C11H10N4O
  • Molecular Weight:214.22
  • Hs Code.:29339900
  • European Community (EC) Number:806-238-9
  • UNII:12P6IK4ZUX
  • ChEMBL ID:CHEMBL4283263
  • Pharos Ligand ID:NZH1X9CCJ3HH
  • Wikidata:Q27216142
  • Mol file:926259-99-6.mol
N-(2-aminophenyl)pyrazine-2-carboxamide

Synonyms:BG45;926259-99-6;N-(2-aminophenyl)pyrazine-2-carboxamide;BG-45;N-(2-Aminophenyl)-2-pyrazinecarboxamide;12P6IK4ZUX;UNII-12P6IK4ZUX;2-Pyrazinecarboxamide, N-(2-aminophenyl)-;CHEMBL4283263;BG45, HDAC3 Inhibitor;SCHEMBL18064956;CHEBI:125522;LMWPVSNHKACEKW-UHFFFAOYSA-N;BCP15990;BMB25999;BDBM50470567;BG-45?;MFCD09046162;s7689;AKOS002434526;CCG-266677;CS-5084;NCGC00402247-01;AS-16428;HY-18712;EN300-199584;S11952;ethyl 3-(4-fluorophenyl)-3-oxopropanoate;A856607;BRD-K27756844-001-02-7;Q27216142;Z239120470

Suppliers and Price of N-(2-aminophenyl)pyrazine-2-carboxamide
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • BG45
  • 100mg
  • $ 715.00
  • Sigma-Aldrich
  • BG45 ≥98% (HPLC)
  • 25mg
  • $ 400.00
  • Sigma-Aldrich
  • BG45 ≥98% (HPLC)
  • 5mg
  • $ 102.00
  • Frontier Specialty Chemicals
  • BG45,98%,aHDACclassIinhibitorwithselectivityforHDAC3 98%
  • 10mg
  • $ 163.00
  • Frontier Specialty Chemicals
  • BG45,98%,aHDACclassIinhibitorwithselectivityforHDAC3 98%
  • 50mg
  • $ 536.00
  • DC Chemicals
  • BG-45 >98%
  • 1 g
  • $ 1450.00
  • DC Chemicals
  • BG-45 >98%
  • 100 mg
  • $ 400.00
  • DC Chemicals
  • BG-45 >98%
  • 250 mg
  • $ 700.00
  • Crysdot
  • BG45 98+%
  • 50mg
  • $ 318.00
  • Crysdot
  • BG45 98+%
  • 100mg
  • $ 491.00
Total 15 raw suppliers
Chemical Property of N-(2-aminophenyl)pyrazine-2-carboxamide
Chemical Property:
  • PSA：80.90000 
  • LogP:1.96530 
  • Storage Temp.:2-8°C 
  • Solubility.:DMSO: soluble20mg/mL, clear 
  • XLogP3:0.3
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:4
  • Rotatable Bond Count:2
  • Exact Mass:214.08546096
  • Heavy Atom Count:16
  • Complexity:246
Purity/Quality:

99%, *data from raw suppliers

BG45 *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes:Xi 
  • Statements: 36/37/38 
  • Safety Statements: 36/37/39 
MSDS Files:
Useful:
  • Canonical SMILES:C1=CC=C(C(=C1)N)NC(=O)C2=NC=CN=C2
  • Description BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively). At concentrations up to 50 mg/kg, BG45 alone or in combination with bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.
  • Uses BG45 acts as an HDAC class I inhibitor with selectvity for HDAC3. HDACs represent novel targets for anti-tumer drugs treating various cancers including multiple myeloma cancer.
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