4-(5-AMINO-6-CHLORO-4-PYRIMIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

Base Information

Chemical Name:4-(5-AMINO-6-CHLORO-4-PYRIMIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
CAS No.:853679-43-3
Molecular Formula:C13H20ClN5O2
Molecular Weight:313.78
Hs Code.:2933990090
Mol file:853679-43-3.mol

Synonyms:4-(5-AMINO-6-CHLORO-4-PYRIMIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER;1-Boc-4-(5-amino-6-chloro-4-pyrimidinyl)piperazine

Suppliers and Price of 4-(5-AMINO-6-CHLORO-4-PYRIMIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl4-(5-amino-6-chloropyrimidin-4-yl)piperazine-1-carboxylate 95+%
1g
$ 518.00

Chemenu
tert-butyl4-(5-amino-6-chloropyrimidin-4-yl)piperazine-1-carboxylate 95%
1g
$ 489.00

American Custom Chemicals Corporation
1-BOC-4-(5-AMINO-6-CHLORO-4-PYRIMIDINYL)PIPERAZINE 95.00%
5MG
$ 502.48

Alichem
tert-Butyl4-(5-amino-6-chloropyrimidin-4-yl)piperazine-1-carboxylate
1g
$ 443.10

Total 3 raw suppliers

Chemical Property of 4-(5-AMINO-6-CHLORO-4-PYRIMIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:468.299°C at 760 mmHg
Flash Point:237.019°C
PSA：84.58000
Density:1.304g/cm³
LogP:2.35340
Storage Temp.:2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

tert-Butyl4-(5-amino-6-chloropyrimidin-4-yl)piperazine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-(5-AMINO-6-CHLORO-4-PYRIMIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

There total 2 articles about 4-(5-AMINO-6-CHLORO-4-PYRIMIDINYL)-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 5413-85-4
5-amino-4,6-dichloropyridimine

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 853679-43-3
tert-butyl 4-(5-amino-6-chloropyrimidin-4-yl)piperazine-1-carboxylate

Guidance literature:: In triethylamine; toluene; for 12h; Heating / reflux;

Reference yield: 91.0%

: 853679-43-3
tert-butyl 4-(5-amino-6-chloropyrimidin-4-yl)piperazine-1-carboxylate

Guidance literature:

Reference yield:

: 853679-43-3
tert-butyl 4-(5-amino-6-chloropyrimidin-4-yl)piperazine-1-carboxylate

: {1-(4-chlorobenzyl)-2-oxo-2-[4-(5H-pyrrolo[3,2-d]pyrimidin-4-yl)-piperazin-1-yl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; triethylamine / 20 h / 80 °C

2.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 4 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 4 h / 20 °C

3.2: 12 h / 20 °C

With hydrogenchloride; copper(l) iodide; potassium tert-butylate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; triethylamine;