3-O-Methyl Colterol

Base Information

Chemical Name:3-O-Methyl Colterol
CAS No.:58868-93-2
Molecular Formula:C13H21NO3
Molecular Weight:239.31074
Hs Code.:
Mol file:58868-93-2.mol

Synonyms:3-O-Methyl Colterol;(+/-)-[(tert-ButylaMino)Methyl]-3-Methoxy-4-hydroxybenzyl Αlcohol;N-tert-ButylMetarterenol;α-[[(1,1-DiMethylethyl)aMino]Methyl]-4-hydroxy-3-MethoxybenzeneMethanol

Suppliers and Price of 3-O-Methyl Colterol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
3-O-Methyl Colterol
50mg
$ 460.00

TRC
3-O-MethylColterol
25mg
$ 185.00

American Custom Chemicals Corporation
3-O-METHYL COLTEROL 95.00%
5MG
$ 504.34

Total 6 raw suppliers

Chemical Property of 3-O-Methyl Colterol

Chemical Property:

Melting Point:140-142°C
Boiling Point:398.3±42.0 °C(Predicted)
PKA:10.03±0.31(Predicted)
PSA：61.72000
Density:1.098±0.06 g/cm3(Predicted)
LogP:2.21320
Storage Temp.:Refrigerator, Under Inert Atmosphere
Solubility.:DMSO (Slightly, Sonicated), Methanol (Slightly)

Purity/Quality:

NLT 98% ^*data from raw suppliers

3-O-Methyl Colterol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses A metabolite of Bitolterol, a new bronchodilator.

Technology Process of 3-O-Methyl Colterol

There total 5 articles about 3-O-Methyl Colterol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₅NO₃*ClH

: 58868-93-2
α-<(tert-butylamino)methyl>-3-methoxy-4-hydroxybenzyl alcohol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 2h; under 7757.43 Torr;
DOI:10.1021/acs.jafc.7b00130

Reference yield:

: 498-02-2
1-(3-methoxy-4-hydroxyphenyl)ethanone

: 58868-93-2
α-<(tert-butylamino)methyl>-3-methoxy-4-hydroxybenzyl alcohol

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

2: bromine / ethanol / 1 h / 20 °C / Inert atmosphere

3: N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

4: hydrogenchloride / dichloromethane / 20 °C

5: palladium 10% on activated carbon; hydrogen / ethanol / 2 h / 20 °C / 7757.43 Torr

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; bromine; potassium carbonate; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jafc.7b00130

Reference yield:

: 1835-11-6
4-benzyloxy-3-methoxyacetophenone

: 58868-93-2
α-<(tert-butylamino)methyl>-3-methoxy-4-hydroxybenzyl alcohol

Guidance literature:: Multi-step reaction with 4 steps

1: bromine / ethanol / 1 h / 20 °C / Inert atmosphere

2: N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

3: hydrogenchloride / dichloromethane / 20 °C

4: palladium 10% on activated carbon; hydrogen / ethanol / 2 h / 20 °C / 7757.43 Torr

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; bromine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jafc.7b00130