Technology Process of (1-Aminocycloheptyl)methanol
There total 5 articles about (1-Aminocycloheptyl)methanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate; sulfuric acid;
In
tetrahydrofuran; diethyl ether;
at 20 ℃;
for 15h;
DOI:10.1021/ja045349r
- Guidance literature:
-
With
sodium bis(2-methoxyethoxy)aluminium dihydride;
In
toluene;
at 0 - 110 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/acscombsci.6b00005
- Guidance literature:
-
Multi-step reaction with 4 steps
1: ammonium chloride; ammonium hydroxide / isopropyl alcohol / 20 °C / Inert atmosphere
2: hydrogenchloride; water / 1,4-dioxane / 8 h / Inert atmosphere; Reflux
3: thionyl chloride / 0 - 20 °C / Inert atmosphere
4: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 2 h / 0 - 110 °C / Inert atmosphere
With
hydrogenchloride; ammonium hydroxide; thionyl chloride; water; ammonium chloride; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
1,4-dioxane; isopropyl alcohol; toluene;
DOI:10.1021/acscombsci.6b00005