Eticlopride hydrochloride

Base Information

Chemical Name:Eticlopride hydrochloride
CAS No.:97612-24-3
Molecular Formula:C17H25 Cl N2 O3 . Cl H
Molecular Weight:377.311
Hs Code.:
UNII:HJ2CAH4TZ1
DSSTox Substance ID:DTXSID4045769
Wikipedia:Eticlopride
ChEMBL ID:CHEMBL1256917

Synonyms:5-chloro-3-ethyl-N-((1-ethyl-2-pyrrolidinyl)methyl)-6-methoxysalicylamide;A 38503;eticlopride;FLB 131;FLB-131

Suppliers and Price of Eticlopride hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
EticloprideHydrochloride
10mg
$ 110.00

Sigma-Aldrich
S-(?)-Eticlopride hydrochloride ≥98% (HPLC), powder
100mg
$ 385.00

Sigma-Aldrich
S-(?)-Eticlopride hydrochloride ≥98% (HPLC), powder
25mg
$ 144.00

Cayman Chemical
Eticlopride (hydrochloride)
25mg
$ 206.00

Cayman Chemical
Eticlopride (hydrochloride)
10mg
$ 99.00

Cayman Chemical
Eticlopride (hydrochloride)
5mg
$ 55.00

ApexBio Technology
Eticlopridehydrochloride
50mg
$ 959.00

ApexBio Technology
Eticlopridehydrochloride
10mg
$ 234.00

Total 5 raw suppliers

Chemical Property of Eticlopride hydrochloride

Chemical Property:

Vapor Pressure:5E-08mmHg at 25°C
Boiling Point:430.8°Cat760mmHg
Flash Point:214.4°C
PSA：61.80000
Density:g/cm³
LogP:3.96150
Storage Temp.:Desiccate at RT
Solubility.:H2O: soluble >10mg/mL
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:376.1320481
Heavy Atom Count:24
Complexity:396

Purity/Quality:

98%,99%, ^*data from raw suppliers

EticloprideHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCC1=CC(=C(C(=C1O)C(=O)NCC2CCCN2CC)OC)Cl.Cl
Isomeric SMILES:CCC1=CC(=C(C(=C1O)C(=O)NC[C@@H]2CCCN2CC)OC)Cl.Cl
Uses Dopamine receptor antagonist S-(?)-Eticlopride hydrochloride has been used in astrocyte-neuron coculture and functional magnetic resonance imaging (fMRI) experiments.

Technology Process of Eticlopride hydrochloride

There total 3 articles about Eticlopride hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 22795-99-9
(S)-2-(Aminomethyl)-1-ethylpyrrolidine

: 101536-78-1
3-chloro-5-ethyl-6-hydroxy-2-methoxybenzoic acid

: 97612-24-3
Eticlopride hydrochloride

Guidance literature:: With thionyl chloride; In toluene; 21 grad C 1h then 50 grad C 0.5h;

Reference yield:

: 98575-96-3
3-Chloro-5-ethyl-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2,6-dimethoxy-benzamide

: 84226-12-0,151060-29-6,151123-04-5,97612-24-3
eticlopride

: 84226-13-1
Isoeticlopride

Guidance literature:: With hydrogenchloride; boron tribromide; In diethyl ether; dichloromethane; for 1.5h; Ambient temperature;
DOI:10.1021/jm00151a010

Reference yield:

: 96897-97-1
2,6-dimethoxy-3-ethylbenzoic acid

: 97612-24-3
Eticlopride hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: HBr/HOAc / H₂O / 1 h / 35 °C

2: 83 percent / sulphuryl chloride / CHCl₃ / 4 h / Ambient temperature

3: 59 percent / thionyl chloride / toluene / 21 grad C 1h then 50 grad C 0.5h

With thionyl chloride; sulfuryl dichloride; hydrogen bromide; acetic acid; In chloroform; water; toluene;