Technology Process of N-(4-{[3-({3-[(3-aminopropyl)amino]propyl}amino)propyl]amino}butyl)-2-(1H-indol-3-yl)acetamide
There total 10 articles about N-(4-{[3-({3-[(3-aminopropyl)amino]propyl}amino)propyl]amino}butyl)-2-(1H-indol-3-yl)acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-[16-amino-5,9,13-tris(2-nitrobenzenesulfonyl)-5,9,13-triazahexadecan-1-yl]-1H-indole-3-acetamide;
With
p-hydroxytrityl-modified polystyrene resin; N-isopropylethylamine;
In
dichloromethane;
at 20 ℃;
With
mercaptoethyl alcohol; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
N,N-dimethyl-formamide;
at 20 ℃;
With
trifluoroacetic acid;
In
dichloromethane;
DOI:10.1016/S0040-4039(99)00851-5
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: Et3N; DMAP / CH2Cl2 / 0.17 h / 20 °C
2.1: 94 percent / Cs2CO3 / acetonitrile / 1 h / 60 °C
3.1: 96 percent / SOCl2 / CH2Cl2; methanol / 1 h
4.1: 4(chlorodiphenylmethyl)phenoxymethylated polystyrene polymer; iPr2NEt / CH2Cl2 / 48 h / 20 °C
4.2: 2-mercaptoethanol; DBU / dimethylformamide / 26 h / 20 °C
4.3: TFA / CH2Cl2 / 0.08 h / 20 °C
With
dmap; thionyl chloride; 4(chlorodiphenylmethyl)phenoxymethylated polystyrene polymer; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine;
In
methanol; dichloromethane; acetonitrile;
DOI:10.1248/cpb.48.1570
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 86 percent / Cs2CO3; nBu4NI / acetonitrile / 1.5 h / 60 °C
2.1: Et3N / CH2Cl2 / 0.17 h / 20 °C
3.1: NaI / butan-2-one / 1 h / 60 °C
4.1: 94 percent / Cs2CO3 / acetonitrile / 1 h / 60 °C
5.1: 96 percent / SOCl2 / CH2Cl2; methanol / 1 h
6.1: 4(chlorodiphenylmethyl)phenoxymethylated polystyrene polymer; iPr2NEt / CH2Cl2 / 48 h / 20 °C
6.2: 2-mercaptoethanol; DBU / dimethylformamide / 26 h / 20 °C
6.3: TFA / CH2Cl2 / 0.08 h / 20 °C
With
thionyl chloride; 4(chlorodiphenylmethyl)phenoxymethylated polystyrene polymer; tetra-(n-butyl)ammonium iodide; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide;
In
methanol; dichloromethane; acetonitrile; butanone;
DOI:10.1248/cpb.48.1570