Boc-D-Met-NH2

Base Information

• Chemical Name: Boc-D-Met-NH2
• CAS No.: 197893-07-5
• Molecular Formula: C10H20N2O3S
• Molecular Weight: 248.34
• Mol file: 197893-07-5.mol

Synonyms:Boc-D-Met-NH2;(R)-tert-Butyl (1-amino-4-(methylthio)-1-oxobutan-2-yl)carbamate

Chemical Property of Boc-D-Met-NH2

Chemical Property:

• Boiling Point: 434.7±40.0 °C(Predicted)
• PKA: 11.15±0.46(Predicted)
• PSA: 106.72000
• Density: 1.123±0.06 g/cm3(Predicted)
• LogP: 2.20930

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Boc-D-Met-NH2

There total 3 articles about Boc-D-Met-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(R)-N-(tert-butoxycarbonyl)methionine (5241-66-7) → Boc-D-Met-NH2 (197893-07-5)

Guidance literature:

(R)-N-(tert-butoxycarbonyl)methionine; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h;

With ammonium chloride; In tetrahydrofuran; water; at 0 ℃; for 0.5h;

DOI:10.1016/j.tetasy.2017.10.015

Reference yield:

D-methionine (348-67-4,26062-47-5,58576-49-1) → Boc-D-Met-NH2 (197893-07-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / H₂O; dioxane / Ambient temperature

2: Boc₂O, pyridine, NH₄HCO₃ / dimethylformamide / Ambient temperature

With pyridine; sodium hydroxide; di-tert-butyl dicarbonate; ammonium bicarbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;

DOI:10.1021/jo990306s

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → Boc-D-Met-NH2 (197893-07-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / H₂O; dioxane / Ambient temperature

2: Boc₂O, pyridine, NH₄HCO₃ / dimethylformamide / Ambient temperature

With pyridine; sodium hydroxide; di-tert-butyl dicarbonate; ammonium bicarbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;

DOI:10.1021/jo990306s

upstream raw materials:

(R)-N-(tert-butoxycarbonyl)methionine

D-methionine

di-tert-butyl dicarbonate

Downstream raw materials:

4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2R)-1-{4-[(4aS,8aR)-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl]piperidin-1-yl}-4-(methylsulfanyl)-1-oxobutan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

tert-butyl [(2R)-1-{4-[(4aS,8aR)-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl]piperidin-1-yl}-4-(methylsulfanyl)-1-oxobutan-2-yl]carbamate

N-(1-oxyl-4'-demethyl-4-deoxypodophyllic)-D-methine amide

(2S,3R)-2-(rel-1S-Ethoxycarbonyl-2-methyl-propyl)-3-(2,2,2-trifluoro-acetylamino)-pyrrolidine-1-carboxylic acid benzyl ester