Axitinib Impurity 4

Base Information

• Chemical Name: Axitinib Impurity 4
• CAS No.: 1443118-73-7
• Molecular Formula: C₂₂H₂₀N₄OS
• Molecular Weight: 388.493
• Mol file: 1443118-73-7.mol

Synonyms:Axitinib Impurity 4;Axitinib Impurity 2

Chemical Property of Axitinib Impurity 4

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Axitinib Impurity 4

There total 9 articles about Axitinib Impurity 4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C8H8NOS(1-)*Na(1+) + C14H12ClN3 → C22H20N4OS (1443118-73-7)

Guidance literature:

for 1h; Heating;

Reference yield:

3-chloro-6-hydroxy-1H-indazole (116570-49-1) → C22H20N4OS (1443118-73-7)

Guidance literature:

Multi-step reaction with 8 steps

1: sodium hydroxide; dimethyl sulfate

2: sodium; magnesium / diethyl ether / Heating

3: hydrogenchloride; zinc(II) chloride / water / Heating

4: 2 h / 300 °C / Sealed tube

5: hydrogen iodide

6: iron(III) chloride; sulfuric acid / water

7: trichlorophosphate; trifluoromethylsulfonic anhydride

8: 1 h / Heating

With hydrogenchloride; iron(III) chloride; trifluoromethylsulfonic anhydride; sulfuric acid; hydrogen iodide; sodium; magnesium; dimethyl sulfate; sodium hydroxide; zinc(II) chloride; trichlorophosphate; In diethyl ether; water;

Reference yield:

C10H12N2O2 → C22H20N4OS (1443118-73-7)

Guidance literature:

Multi-step reaction with 6 steps

1: hydrogenchloride; zinc(II) chloride / water / Heating

2: 2 h / 300 °C / Sealed tube

3: hydrogen iodide

4: iron(III) chloride; sulfuric acid / water

5: trichlorophosphate; trifluoromethylsulfonic anhydride

6: 1 h / Heating

With hydrogenchloride; iron(III) chloride; trifluoromethylsulfonic anhydride; sulfuric acid; hydrogen iodide; zinc(II) chloride; trichlorophosphate; In water;

upstream raw materials:

3-chloro-6-hydroxy-1H-indazole

3-chloro-6-methoxy-1H-indazole

Downstream raw materials:

axitinib

Refernces