N-Boc-(R,S)-Nornicotine

Base Information

• Chemical Name: N-Boc-(R,S)-Nornicotine
• CAS No.: 1076199-53-5
• Molecular Formula: C14H20N2O2
• Molecular Weight: 248.325
• Mol file: 1076199-53-5.mol

Synonyms:2-(3-Pyridinyl)-1-pyrrolidinecarboxylic Acid tert-Butyl Ester;N-Boc-(R,S)-Nornicotine;N-Boc-2-(3-pyridyl)pyrolidine;2-(3-Pyridinyl)-1-pyrrolidinecarboxylic Acid 1,1-DiMethylethyl Ester

Chemical Property of N-Boc-(R,S)-Nornicotine

Chemical Property:

• PSA: 42.43000
• LogP: 3.09150
• Storage Temp.: Amber Vial, Refrigerator, Under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

N-Boc(R,S)-Nornicotine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Boc (R,S)-Nornicotine (cas# 1076199-53-5) is a compound useful in organic synthesis.

Technology Process of N-Boc-(R,S)-Nornicotine

There total 5 articles about N-Boc-(R,S)-Nornicotine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-(4-azidobutyl)pyridine → 2-pyridin-3-ylpyrrolidine-1-carboxylic acid tert-butyl ester (1076199-53-5)

Guidance literature:

With [Fe^III(5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrinato)(1,3-dimethylimidazol-2-ylidene)₂]I; In toluene; at 140 ℃; for 0.583333h; under 7757.43 Torr; Temperature; Microwave irradiation; Sealed tube;

DOI:10.1002/anie.201806059

Reference yield: 71.0%

3-Bromopyridine (626-55-1,163928-56-1) + N-Boc-prolinol (170491-63-1) → 2-pyridin-3-ylpyrrolidine-1-carboxylic acid tert-butyl ester (1076199-53-5)

Guidance literature:

With cerium(III) chloride; 9,10-diphenylanthracene; C₁₂H₂₀N₂NiO₄⁽²⁺⁾*2Cl^(1-); C₁₆H₂₃O₂^(1-)*K⁽¹⁺⁾; sodium phosphate; In dimethyl sulfoxide; acetonitrile; at 20 ℃; for 36h; Glovebox; Sealed tube; Irradiation;

DOI:10.1021/jacs.1c00618

Reference yield: 45.0%

3-Bromopyridine (626-55-1,163928-56-1) + 1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) → 2-pyridin-3-ylpyrrolidine-1-carboxylic acid tert-butyl ester (1076199-53-5)

Guidance literature:

With (1,2-dimethoxyethane)dichloronickel(II); (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 4,4'-di-tert-butyl-2,2'-bipyridine; In N,N-dimethyl acetamide; at 40 ℃; for 0.5h; Irradiation; Inert atmosphere;

DOI:10.1016/j.bmc.2016.12.041

upstream raw materials:

3-Bromopyridine

1-(tert-butoxycarbonyl)-L-proline

di-tert-butyl dicarbonate

1-(4-azidobutyl)benzene

Downstream raw materials:

nornicotine

(+)-nornicotine

rac-nornicotine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1076199-53-5 N-Boc-(R,S)-Nornicotine

Send

Send

Metric Ton KG G Pound L ML

Send

Send