cis-2,6-Dimethyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: cis-2,6-Dimethyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 1005397-64-7
• Molecular Formula: C12H21NO3
• Molecular Weight: 227.3
• Mol file: 1005397-64-7.mol

Synonyms:cis-2,6-Dimethyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of cis-2,6-Dimethyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

• Boiling Point: 308.2±35.0 °C(Predicted)
• PKA: -1.46±0.60(Predicted)
• PSA: 46.61000
• Density: 1.027±0.06 g/cm3(Predicted)
• LogP: 2.30130
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

(2R,6S)-tert-Butyl2,6-Dimethyl-4-oxopiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cis-2,6-Dimethyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester

There total 6 articles about cis-2,6-Dimethyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

di-tert-butyl dicarbonate (24424-99-5) + (2S,6R)-2,6-dimethylpiperidin-4-one (13200-35-6) → tert-butyl-cis-2,6-dimethyl-4-oxopiperidine-1-carboxylate (1005397-64-7,184368-70-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

cis/trans-2,6-dimethylpiperidinone + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl-cis-2,6-dimethyl-4-oxopiperidine-1-carboxylate (1005397-64-7,184368-70-5) + trans-2,6-dimethyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester (1268816-80-3,184368-70-5)

Guidance literature:

With sodium hydroxide; In diethyl ether; water; at 20 ℃; for 48h;

Reference yield:

(2S,6S)-2,6-dimethylpiperidin-4-one + di-tert-butyl dicarbonate (24424-99-5) + (2S,6R)-2,6-dimethylpiperidin-4-one (13200-35-6) → tert-butyl-cis-2,6-dimethyl-4-oxopiperidine-1-carboxylate (1005397-64-7,184368-70-5) + trans-2,6-dimethyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester (1268816-80-3,184368-70-5)

Guidance literature:

With sodium hydroxide; In diethyl ether; water; at 20 ℃; for 48h;

upstream raw materials:

di-tert-butyl dicarbonate

(2S,6R)-2,6-dimethylpiperidin-4-one

(2R,6S)-1-benzyl-2,6-dimethylpiperidin-4-one

Downstream raw materials:

tert-butyl (2S,6R)-4-hydroxy-2,6-dimethyl-piperidine-1-carboxylate

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