ethyl 6-hydroxy-1-benzofuran-2-carboxylate

Base Information

• Chemical Name: ethyl 6-hydroxy-1-benzofuran-2-carboxylate
• CAS No.: 906448-92-8
• Molecular Formula: C11H10O4
• Molecular Weight: 206.198
• Hs Code.: 2932999099
• Mol file: 906448-92-8.mol

Synonyms:ethyl 6-hydroxy-1-benzofuran-2-carboxylate;Ethyl 6-hydroxybenzofuran-2-carboxylate

Chemical Property of ethyl 6-hydroxy-1-benzofuran-2-carboxylate

Chemical Property:

• Melting Point: 156 °C
• Boiling Point: 237.0±10.0 °C(Predicted)
• PKA: 8.47±0.40(Predicted)
• PSA: 59.67000
• Density: 1.295±0.06 g/cm3(Predicted)
• LogP: 2.31510

Purity/Quality:

97% ^*data from raw suppliers

Ethyl6-hydroxybenzofuran-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 6-hydroxy-1-benzofuran-2-carboxylate

There total 3 articles about ethyl 6-hydroxy-1-benzofuran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-benzoxy-salicylaldehyde (52085-14-0) → 6-hydroxy-benzofuran-2-carboxylic acid ethyl ester (906448-92-8)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃; acetone

2: sodium ethylate; ethanol

3: palladium/charcoal; acetic acid / Hydrogenation

With palladium on activated charcoal; ethanol; sodium ethanolate; potassium carbonate; acetic acid; acetone;

Reference yield:

6-benzyloxy-benzofuran-2-carboxylic acid ethyl ester (110060-70-3) → 6-hydroxy-benzofuran-2-carboxylic acid ethyl ester (906448-92-8)

Guidance literature:

With palladium on activated charcoal; acetic acid; Hydrogenation;

Reference yield:

4-benzyloxy-2-[ethyloxycarbonylmethoxy]benzaldehyde (412300-65-3) → 6-hydroxy-benzofuran-2-carboxylic acid ethyl ester (906448-92-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium ethylate; ethanol

2: palladium/charcoal; acetic acid / Hydrogenation

With palladium on activated charcoal; ethanol; sodium ethanolate; acetic acid;

upstream raw materials:

6-benzyloxy-benzofuran-2-carboxylic acid ethyl ester

4-benzyloxy-2-[ethyloxycarbonylmethoxy]benzaldehyde

4-benzoxy-salicylaldehyde

Downstream raw materials:

6-hydroxybenzofuran