CCG-203971

Base Information

• Chemical Name: CCG-203971
• CAS No.: 1443437-74-8
• Molecular Formula: C23H21ClN2O3
• Molecular Weight: 408.884
• Mol file: 1443437-74-8.mol

Synonyms:CCG-203971

Chemical Property of CCG-203971

Chemical Property:

• Boiling Point: 656.0±55.0 °C(Predicted)
• PKA: 13.69±0.70(Predicted)
• PSA: 62.55000
• Density: 1.305±0.06 g/cm3(Predicted)
• LogP: 5.10180
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

CCG-203971 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: CCG 203971 acts as an antifibrotic agent, inhibiting fibrosis through targeting the MRTF/SRF gene transcription pathway. Inhibits the invasion of prostate cancer cells and acts as a potent anti-proliferative agent.

Technology Process of CCG-203971

There total 6 articles about CCG-203971 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

3-(furan-2-yl)benzoic acid (35461-99-5) + N-(4-chlorophenyl)piperidine-3-carboxamide trifluoroacetate → N-(4-chlorophenyl)-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide (1443437-74-8)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

Reference yield:

N-(tert-butyloxycarbonyl)nipecotic acid (71381-75-4,88495-54-9,84358-12-3) → N-(4-chlorophenyl)-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide (1443437-74-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane

2: trifluoroacetic acid / dichloromethane / -10 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane; N,N-dimethyl-formamide

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.04.080

Reference yield:

tert-butyl 3-(4-chlorophenylcarbamoyl)piperidine-1-carboxylic acid ester → N-(4-chlorophenyl)-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide (1443437-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / -10 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane; N,N-dimethyl-formamide

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.04.080

upstream raw materials:

nipecotic acid

N-(tert-butyloxycarbonyl)nipecotic acid

3-(furan-2-yl)benzoic acid

4-chloro-aniline