Tert-butyl 4-(aminomethyl)-4-methoxypiperidine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 4-(aminomethyl)-4-methoxypiperidine-1-carboxylate
CAS No.:863561-70-0
Molecular Formula:C12H24N2O3
Molecular Weight:244.333
Hs Code.:
European Community (EC) Number:846-042-0
DSSTox Substance ID:DTXSID30694597
Mol file:863561-70-0.mol

Synonyms:863561-70-0;1-Boc-4-aminomethyl-4-methoxypiperidine;tert-butyl 4-(aminomethyl)-4-methoxypiperidine-1-carboxylate;SCHEMBL12113151;DTXSID30694597;ZIYOADOXUKBYLJ-UHFFFAOYSA-N;MFCD11845432;AKOS023398539;1-Piperidinecarboxylic acid, 4-(aminomethyl)-4-methoxy-, 1,1-dimethylethyl ester;PS-20529;CS-0091213;FT-0735602;D75050;EN300-207478;tert-butyl4-(aminomethyl)-4-methoxypiperidine-1-carboxylate;4-aminomethyl-4-methoxy-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid,4-(aminomethyl)-4-methoxy-,1,1-dimethylethyl ester

Suppliers and Price of Tert-butyl 4-(aminomethyl)-4-methoxypiperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-BOC-4-AMINOMETHYL-4-METHOXYPIPERIDINE 95.00%
5MG
$ 501.46

AK Scientific
Tert-butyl4-(aminomethyl)-4-methoxypiperidine-1-carboxylate
5g
$ 2815.00

Aaron Chemicals
tert-butyl4-(aminomethyl)-4-methoxypiperidine-1-carboxylate 95%
1g
$ 886.00

Total 7 raw suppliers

Chemical Property of Tert-butyl 4-(aminomethyl)-4-methoxypiperidine-1-carboxylate

Chemical Property:

Boiling Point:322.6±27.0 °C(Predicted)
PKA:10.13±0.29(Predicted)
PSA：64.79000
Density:1.06±0.1 g/cm3(Predicted)
LogP:1.99940
XLogP3:0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:244.17869263
Heavy Atom Count:17
Complexity:265

Purity/Quality:

97% ^*data from raw suppliers

1-BOC-4-AMINOMETHYL-4-METHOXYPIPERIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)(CN)OC

Technology Process of Tert-butyl 4-(aminomethyl)-4-methoxypiperidine-1-carboxylate

There total 3 articles about Tert-butyl 4-(aminomethyl)-4-methoxypiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 863561-69-7
tert-butyl 4-(azidomethyl)-4-methoxypiperidine-1-carboxylate

: 863561-70-0
tert-butyl 4-(aminomethyl)-4-methoxypiperidine-1-carboxylate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; ethyl acetate; for 2.5h; under 912.061 Torr;

Reference yield:

: 863561-68-6
tert-butyl 4-(azidomethyl)-4-hydroxypiperidine-1-carboxylate

: 863561-70-0
tert-butyl 4-(aminomethyl)-4-methoxypiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 15-crown-5; sodium hydride / tetrahydrofuran

2: hydrogen / palladium 10% on activated carbon / ethanol; ethyl acetate / 2.5 h / 912.06 Torr

With 15-crown-5; hydrogen; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; ethyl acetate;

Reference yield:

: 147804-30-6
1-oxa-6-aza-spiro-[2.5]octane-6-caboxylic acid tert-butyl ester

: 863561-70-0
tert-butyl 4-(aminomethyl)-4-methoxypiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide; ammonium chloride / methanol; water / 15 h / Heating / reflux

2: 15-crown-5; sodium hydride / tetrahydrofuran

3: hydrogen / palladium 10% on activated carbon / ethanol; ethyl acetate / 2.5 h / 912.06 Torr

With sodium azide; 15-crown-5; hydrogen; sodium hydride; ammonium chloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; ethyl acetate;