6-chloro-5-(4-chlorophenyl)nicotinic acid

Base Information

Chemical Name:6-chloro-5-(4-chlorophenyl)nicotinic acid
CAS No.:1012792-56-1
Molecular Formula:C12H7Cl2NO2
Molecular Weight:268.099
Hs Code.:
Mol file:1012792-56-1.mol

Synonyms:6-chloro-5-(4-chlorophenyl)nicotinic acid;Pyridine-3-carboxylic acid, 6-chloro-5-(4-chlorophenyl)-;6-chloro-5-(4-chlorophenyl)-3-pyridinecarboxylic acid

Suppliers and Price of 6-chloro-5-(4-chlorophenyl)nicotinic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 6-chloro-5-(4-chlorophenyl)nicotinic acid

Chemical Property:

PSA：50.19000
LogP:3.75360

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-chloro-5-(4-chlorophenyl)nicotinic acid

There total 5 articles about 6-chloro-5-(4-chlorophenyl)nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1012792-55-0
6-chloro-5-(4-chlorophenyl)-3-pyridinecarboxylic acid methyl ester

: 1012792-56-1
6-chloro-5-(4-chlorophenyl)-3-pyridinecarboxylic acid

Guidance literature:: 6-chloro-5-(4-chlorophenyl)-3-pyridinecarboxylic acid methyl ester; With lithium hydroxide; In tetrahydrofuran; water; for 1h; Heating / reflux;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

: 78686-77-8
5-bromo-6-chloro-3-pyridinecarboxylic acid methyl ester

: 1012792-56-1
6-chloro-5-(4-chlorophenyl)-3-pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / toluene; water / 1 h / 90 °C / Inert atmosphere

2: lithium hydroxide monohydrate / water; tetrahydrofuran / 1 h / Inert atmosphere; Reflux

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium hydroxide monohydrate; sodium carbonate; In tetrahydrofuran; water; toluene;
DOI:10.1021/jm4010708

Reference yield:

: 29241-62-1
5-bromo-6-chloronicotinic acid

: 1012792-56-1
6-chloro-5-(4-chlorophenyl)-3-pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 1.25 h / 70 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / toluene; water / 1 h / 90 °C / Inert atmosphere

3: lithium hydroxide monohydrate / water; tetrahydrofuran / 1 h / Inert atmosphere; Reflux

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium hydroxide monohydrate; sodium carbonate; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1021/jm4010708