6-AMinoMethyl-2-Boc-2-aza-spiro[3.3]heptane

Base Information

• Chemical Name: 6-AMinoMethyl-2-Boc-2-aza-spiro[3.3]heptane
• CAS No.: 1363380-79-3
• Molecular Formula: C₁₂H₂₂N₂O₂
• Molecular Weight: 226.319
• Mol file: 1363380-79-3.mol

Synonyms:6-AMinoMethyl-2-Boc-2-aza-spiro[3.3]heptane;tert-butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate

Chemical Property of 6-AMinoMethyl-2-Boc-2-aza-spiro[3.3]heptane

Chemical Property:

• Boiling Point: 321.8±15.0 °C(Predicted)
• PKA: 10.12±0.29(Predicted)
• Density: 1.10±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

tert-butyl6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-AMinoMethyl-2-Boc-2-aza-spiro[3.3]heptane

There total 3 articles about 6-AMinoMethyl-2-Boc-2-aza-spiro[3.3]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tert-butyl 6-cyano-2-azaspiro[3.3]heptane-2-carboxylate (1374658-94-2) → tert-butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate (1363380-79-3)

Guidance literature:

With ammonium hydroxide; hydrogen; In methanol; at 25 ℃; for 4h; under 2585.81 Torr;

Reference yield:

tert-butyl 6-((methylsulfonyl)oxy)-2-azaspiro[3.3]heptane-2-carboxylate (1239320-11-6) → tert-butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate (1363380-79-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 18 h / 100 °C / Inert atmosphere

2: hydrogen; ammonium hydroxide / methanol / 4 h / 25 °C / 2585.81 Torr

With ammonium hydroxide; hydrogen; In methanol; N,N-dimethyl-formamide;

Reference yield:

6-hydroxy-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester (1147557-97-8) → tert-butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate (1363380-79-3)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 2 h / 0 - 25 °C / Inert atmosphere

2: N,N-dimethyl-formamide / 18 h / 100 °C / Inert atmosphere

3: hydrogen; ammonium hydroxide / methanol / 4 h / 25 °C / 2585.81 Torr

With ammonium hydroxide; hydrogen; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl 6-((methylsulfonyl)oxy)-2-azaspiro[3.3]heptane-2-carboxylate

tert-butyl 6-cyano-2-azaspiro[3.3]heptane-2-carboxylate

6-hydroxy-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester

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