2-(4-Methylpiperazin-1-yl)pyrimidin-5-amine

Base Information

• Chemical Name: 2-(4-Methylpiperazin-1-yl)pyrimidin-5-amine
• CAS No.: 943757-74-2
• Molecular Formula: C9H15N5
• Molecular Weight: 193.2489
• Hs Code.: 2933990090
• Mol file: 943757-74-2.mol

Synonyms:2-(4-Methylpiperazin-1-yl)pyrimidin-5-amine;2-(4-methyl-1-piperazinyl)-5-pyrimidinamine

Chemical Property of 2-(4-Methylpiperazin-1-yl)pyrimidin-5-amine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 386.316ºC at 760 mmHg
• PKA: 7.37±0.42(Predicted)
• Flash Point: 187.437ºC
• PSA: 58.28000
• Density: 1.197g/cm3
• LogP: 0.39470
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

2-(4-methylpiperazin-1-yl)pyrimidin-5-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Methylpiperazin-1-yl)pyrimidin-5-amine

There total 3 articles about 2-(4-Methylpiperazin-1-yl)pyrimidin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-(4-methylpiperazin-1-yl)-5-nitropyrimidine (943749-60-8) → [2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]amine (943757-74-2)

Guidance literature:

With iron; acetic acid; In methanol;

DOI:10.1021/jm800072z

Reference yield: 46.0%

→ [2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]amine (943757-74-2)

Guidance literature:

With ammonium chloride; In tetrahydrofuran; methanol; water; at 27 ℃; for 2h;

Reference yield:

1-methyl-piperazine (109-01-3) → [2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]amine (943757-74-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate; tetra-(n-butyl)ammonium iodide / dimethyl sulfoxide / 3 h / 90 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C

With palladium 10% on activated carbon; hydrogen; tetra-(n-butyl)ammonium iodide; sodium carbonate; In methanol; dimethyl sulfoxide;

DOI:10.1021/acs.jmedchem.1c00104

upstream raw materials:

2-(4-methylpiperazin-1-yl)-5-nitropyrimidine

1-methyl-piperazine