Pilocarpic Acid SodiuM Salt

Base Information

• Chemical Name: Pilocarpic Acid SodiuM Salt
• CAS No.: 92598-79-3
• Molecular Formula: C11H17N2NaO3
• Molecular Weight: 248.25405
• Mol file: 92598-79-3.mol

Synonyms:Pilocarpic Acid SodiuM Salt;[S-(R*,S*)]-α-Ethyl-β-(hydroxyMethyl)-1-Methyl-1H-IMidazole-5-butanoic Acid MonosodiuM Salt

Chemical Property of Pilocarpic Acid SodiuM Salt

Chemical Property:

• PSA: 78.18000
• LogP: -0.65280
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Methanol (Slightly), Water (Slightly, Heated, Sonicated)

Purity/Quality:

98% ^*data from raw suppliers

PilocarpicAcidSodiumSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An imidazole derivative, Pilocarpic Acid SodiuM Salt can be used in the preparation of novel sequentially labile pilocarpine prodrugs for improved ocular delivery. Pilocarpic Acid Sodium Salt is an imidazole derivative used in the preparation of novel sequentially labile pilocarpine prodrugs for improved ocular delivery.

Technology Process of Pilocarpic Acid SodiuM Salt

There total 1 articles about Pilocarpic Acid SodiuM Salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pilocarpine hydrochloride (54-71-7) → sodium isopilocarpate (101769-87-3) + sodium pilocarpate (92598-79-3)

Guidance literature:

With sodium hydroxide; In water; at 0 - 4 ℃; for 1h; Yield given;

DOI:10.1002/jps.2600750109

Reference yield: 18.0%

sodium pilocarpate (92598-79-3) → (2S,3R)-2-Ethyl-3-hydroxymethyl-4-(3-methyl-3H-imidazol-4-yl)-butyric acid 4-tert-butyl-benzyl ester (92598-99-7)

Guidance literature:

In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1002/jps.2600750109

Reference yield:

sodium pilocarpate (92598-79-3) → (2S,3R)-2-Ethyl-3-hydroxymethyl-4-(3-methyl-3H-imidazol-4-yl)-butyric acid 4-tert-butyl-benzyl ester (92598-99-7)

Guidance literature:

In N,N-dimethyl-formamide;

DOI:10.1021/jm00146a001

upstream raw materials:

pilocarpine hydrochloride

Downstream raw materials:

(2S,3R)-2-Ethyl-3-hydroxymethyl-4-(3-methyl-3H-imidazol-4-yl)-butyric acid 4-tert-butyl-benzyl ester