2-Phenyl-5,6-dihydropyrazolo[5,1-a]isoquinoline

Base Information

• Chemical Name: 2-Phenyl-5,6-dihydropyrazolo[5,1-a]isoquinoline
• CAS No.: 61001-31-8
• Molecular Formula: C17H14N2
• Molecular Weight: 246.312
• Hs Code.: 2933990090
• Mol file: 61001-31-8.mol

Synonyms:5,6-Dihydro-2-phenylpyrazolo(5,1-a)isoquinoline;2-phenyl-5,6-dihydro-pyrazolo<5,1-a>CTK8J6376;Pyrazolo(5,1-a)isoquinoline,5,6-dihydro-2-phenyl;2-phenyl-5,6-dihydro-pyrazolo[5,1-a]isoquinoline;

Chemical Property of 2-Phenyl-5,6-dihydropyrazolo[5,1-a]isoquinoline

Chemical Property:

• Vapor Pressure: 2.96E-08mmHg at 25°C
• Refractive Index: 1.5794 (estimate)
• Boiling Point: 461.4°Cat760mmHg
• Flash Point: 232.8°C
• PSA: 17.82000
• Density: 1.18g/cm³
• LogP: 3.77320

Purity/Quality:

99% ^*data from raw suppliers

2-PHENYL-5,6-DIHYDROPYRAZOLO-[5,1-A]ISOQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Phenyl-5,6-dihydropyrazolo[5,1-a]isoquinoline

There total 14 articles about 2-Phenyl-5,6-dihydropyrazolo[5,1-a]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-phenyl-1,5,6,10b-tetrahydropyrazolo[5,1-a]isoquinoline → 2-phenyl-5,6-dihydro-pyrazolo<5,1-a>isoquinoline (61001-31-8)

Guidance literature:

at 120 ℃; for 3h;

DOI:10.1021/acs.orglett.9b02978

Reference yield: 87.0%

2-phenyl-5,6-dihydro-pyrazolo<5,1-a>isoquinoline-1-carboxylic acid (61001-28-3) → 2-phenyl-5,6-dihydro-pyrazolo<5,1-a>isoquinoline (61001-31-8)

Guidance literature:

With sulfuric acid; In ethanol; for 11h; Heating;

Reference yield: 84.0%

(3,7b-dihydro-2H-1,1a-diazacyclopropa[a]naphthalen-1-yl)-(4-methoxyphenyl)methanone (1006061-06-8) + phenylacetylene (536-74-3) → 2-phenyl-5,6-dihydro-pyrazolo<5,1-a>isoquinoline (61001-31-8)

Guidance literature:

With oxygen; In chloroform; at 50 ℃; for 48h; under 760.051 Torr;

DOI:10.1055/s-2007-990888

upstream raw materials:

2-phenyl-5,6-dihydro-pyrazolo<5,1-a>isoquinoline-1-carboxylic acid

2-amino-3,4-dihydro-1(2H)-isoquinolinone

ethyl 3-oxo-3-phenylpropionate

ethyl β<(1-oxo-3,4-dihydro-2H-isoquinolyl)amino>cynnamate

Downstream raw materials:

2-phenyl-pyrazolo<5,1-a>isoquinoline

Refernces

• 1、 -. "2-substituted 5,6-dihydropyrazolo[5,1-alpha]isoquinoline and derivative and synthesis method thereof". Paragraph 0043-0050; 0075. . Retrieved 2019/10/15.
• 2、 Ortega, Heriberto,Ahmed, Sara,Alper, Howard. "Facile regioselective synthesis of pyrazolo[5,1-α]isoquinolines via ring-opening cyclization/oxidation reactions of stable aroyldiaziridines of 3,4-tetrahydroisoquinoline with alkynes". . p. 3683 - 3691. Retrieved 2008/09/19.