Technology Process of (R)-2-AMINO-7-HYDROXYTETRALIN HYBROMIDE
There total 6 articles about (R)-2-AMINO-7-HYDROXYTETRALIN HYBROMIDE which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen bromide;
In
water;
Reflux;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dichloromethane / 0.25 h / Inert atmosphere
1.2: 15 h / 20 °C / Inert atmosphere
2.1: 20 % Pd(OH)2/C; hydrogen; acetic acid / ethanol / 24.08 h / 20 °C
3.1: sodium hydroxide / water; ethyl acetate
4.1: methanol; water; isopropyl alcohol; toluene / 0.5 h / Reflux
5.1: sodium hydroxide / water; ethyl acetate
6.1: water; hydrogen bromide / 1.75 h / Reflux
With
20 % Pd(OH)2/C; water; hydrogen bromide; hydrogen; acetic acid; sodium hydroxide;
In
methanol; ethanol; dichloromethane; water; ethyl acetate; isopropyl alcohol; toluene;
DOI:10.1021/jm101479y
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 20 % Pd(OH)2/C; hydrogen; acetic acid / ethanol / 24.08 h / 20 °C
2: sodium hydroxide / water; ethyl acetate
3: methanol; water; isopropyl alcohol; toluene / 0.5 h / Reflux
4: sodium hydroxide / water; ethyl acetate
5: water; hydrogen bromide / 1.75 h / Reflux
With
20 % Pd(OH)2/C; water; hydrogen bromide; hydrogen; acetic acid; sodium hydroxide;
In
methanol; ethanol; water; ethyl acetate; isopropyl alcohol; toluene;
DOI:10.1021/jm101479y
