Technology Process of 2-Ethyl-1,2,3,4,6,11-hexahydro-2,4,5,7,10-pentahydroxy-6,11-dioxo-1-naphthacenecarboxylic acid methyl ester
There total 6 articles about 2-Ethyl-1,2,3,4,6,11-hexahydro-2,4,5,7,10-pentahydroxy-6,11-dioxo-1-naphthacenecarboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,2'-azobis(isobutyronitrile); bromine;
1.) carbon tetrachloride, reflux, 2 h, 2.) tetrahydrofuran-water, 2h, r.t.;
DOI:10.1021/ja00316a048
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 93 percent / 1.) potassium carbonate, 2.) triethylamine / 1.) acetone, reflux, 8 h, 2.) ethyl acetate, r.t., 0.5 h
2: 93 percent / hydrochloride acid, H2 / 10percent Pd/C / methanol / 1 h / 1137.7 Torr / Ambient temperature
3: 93 percent / pyridinium chlorochromate / CH2Cl2 / 3 h / Ambient temperature
4: 156 mg / magnesium methoxide / methanol / 5 h / Ambient temperature
5: 94 percent / aluminium chloride / CH2Cl2 / 2 h / Ambient temperature
6: 96 percent / 1.) AIBN, bromine / 1.) carbon tetrachloride, reflux, 2 h, 2.) tetrahydrofuran-water, 2h, r.t.
With
hydrogenchloride; aluminium trichloride; 2,2'-azobis(isobutyronitrile); hydrogen; bromine; potassium carbonate; magnesium methanolate; triethylamine; pyridinium chlorochromate;
palladium on activated charcoal;
In
methanol; dichloromethane;
DOI:10.1021/ja00316a048
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 93 percent / hydrochloride acid, H2 / 10percent Pd/C / methanol / 1 h / 1137.7 Torr / Ambient temperature
2: 93 percent / pyridinium chlorochromate / CH2Cl2 / 3 h / Ambient temperature
3: 156 mg / magnesium methoxide / methanol / 5 h / Ambient temperature
4: 94 percent / aluminium chloride / CH2Cl2 / 2 h / Ambient temperature
5: 96 percent / 1.) AIBN, bromine / 1.) carbon tetrachloride, reflux, 2 h, 2.) tetrahydrofuran-water, 2h, r.t.
With
hydrogenchloride; aluminium trichloride; 2,2'-azobis(isobutyronitrile); hydrogen; bromine; magnesium methanolate; pyridinium chlorochromate;
palladium on activated charcoal;
In
methanol; dichloromethane;
DOI:10.1021/ja00316a048
