Methoxyphenamine hydrochloride

Base Information

• Chemical Name: Methoxyphenamine hydrochloride
• CAS No.: 5588-10-3
• Molecular Formula: C11H17NO^.HCl
• Molecular Weight: 215.723
• Hs Code.: 2942000000
• European Community (EC) Number: 226-993-2
• NSC Number: 65644
• UNII: 52V8BVV7FX
• DSSTox Substance ID: DTXSID301026187
• Wikidata: Q27261024
• NCI Thesaurus Code: C83959
• ChEMBL ID: CHEMBL1985928
• Mol file: 5588-10-3.mol

Synonyms:1-(2-methoxyphenyl)-2-methylaminopropane;2-methoxy-N,alpha-dimethylphenethylamine;methoxyphenamine;methoxyphenamine hydrochloride;methoxyphenamine hydrochloride, (+-)-isomer;methoxyphenamine hydrochloride, (R)-isomer;methoxyphenamine, (S)-isomer;mimexina;Orthoxine

Chemical Property of Methoxyphenamine hydrochloride

Chemical Property:

• Vapor Pressure: 0.0194mmHg at 25°C
• Melting Point: 210°C
• Boiling Point: 252.3 °C at 760 mmHg
• Flash Point: 102.6 °C
• PSA: 21.26000
• Density: 0.951 g/cm3
• LogP: 3.03850
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 215.1076919
• Heavy Atom Count: 14
• Complexity: 138

Purity/Quality:

99% ^*data from raw suppliers

Methoxyphenamine hydrochloride ≥99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(CC1=CC=CC=C1OC)NC.Cl
• Uses: Methoxyphenamine hydrochloride, is the salt version of methoxyphenamine (OMMA), a β-adrenergic receptor agonist, that regulates norephinephrine and ephinephrinein concentrations.

Technology Process of Methoxyphenamine hydrochloride

There total 2 articles about Methoxyphenamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methoxyphenamine (93-30-1) → (+-)-[2-(2-methoxy-phenyl)-1-methyl-ethyl]-methyl-amine; hydrochloride (5588-10-3)

Guidance literature:

With hydrogenchloride; In water; at -6 ℃; for 12h; pH=2; Temperature; pH-value;

Reference yield:

1-(2-methoxyphenyl)propan-2-one (5211-62-1) → (+-)-[2-(2-methoxy-phenyl)-1-methyl-ethyl]-methyl-amine; hydrochloride (5588-10-3)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 15 h / 28 °C

2: lithium aluminium tetrahydride / 7 h / 2 °C

3: hydrogenchloride / water / 12 h / -6 °C / pH 2

With hydrogenchloride; lithium aluminium tetrahydride; In methanol; water;

Reference yield:

(+-)-[2-(2-methoxy-phenyl)-1-methyl-ethyl]-methyl-amine; hydrochloride (5588-10-3) → 1-<2-(2-Methoxy-phenyl)-1-methyl-aethyl>-1-methyl-hydrazin (104116-49-6)

Guidance literature:

Multistep reaction; (i) NaNO₂, aq. H₂SO₄, (ii) aq. KOH, (iii) LiAlH₄;

DOI:10.1021/jm50016a015

upstream raw materials:

1-(2-methoxyphenyl)propan-2-one

methoxyphenamine

Downstream raw materials:

1-<2-(2-Methoxy-phenyl)-1-methyl-aethyl>-1-methyl-hydrazin

Refernces