4-CHLORO-3-FLUORO-DL-PHENYLALANINE

Base Information

• Chemical Name: 4-CHLORO-3-FLUORO-DL-PHENYLALANINE
• CAS No.: 439587-16-3
• Molecular Formula: C₉H₉ClFNO₂
• Molecular Weight: 217.627
• Hs Code.: 2922499990
• Mol file: 439587-16-3.mol

Synonyms:4-CHLORO-3-FLUORO-DL-PHENYLALANINE;DL-4-CHLORO-3-FLUOROPHENYLALANINE

Chemical Property of 4-CHLORO-3-FLUORO-DL-PHENYLALANINE

Chemical Property:

• PSA: 63.32000
• LogP: 2.13380

Purity/Quality:

99%+, ^*data from raw suppliers

4-Chloro-3-fluoro-DL-phenylalanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-CHLORO-3-FLUORO-DL-PHENYLALANINE

There total 2 articles about 4-CHLORO-3-FLUORO-DL-PHENYLALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[1-(4-Chloro-3-fluoro-phenyl)-meth-(Z)-ylidene]-2-methyl-4H-oxazol-5-one → DL-4-chloro-3-fluorophenylalanine (439587-16-3)

Guidance literature:

With hydrogen iodide; acetic anhydride; for 3.5h; Heating;

DOI:10.1081/SCC-120002709

Reference yield:

4-chloro-3-fluorobenzaldehyde (5527-95-7) → DL-4-chloro-3-fluorophenylalanine (439587-16-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOAc; Ac₂O / 0.5 h / 110 - 115 °C

2: P; 47 percent HI; Ac₂O / 3.5 h / Heating

With hydrogen iodide; sodium acetate; acetic anhydride; 1: Erlenmeyer reaction;

DOI:10.1081/SCC-120002709

upstream raw materials:

4-chloro-3-fluorobenzaldehyde

Refernces