N,N,N',N'-tetrakis(1-Methylethyl)phosphorodiamidous acid phenylmethyl ester

Base Information

• Chemical Name: N,N,N',N'-tetrakis(1-Methylethyl)phosphorodiamidous acid phenylmethyl ester
• CAS No.: 108549-21-9
• Molecular Formula: C₁₉H₃₅N₂OP
• Molecular Weight: 338.473
• Mol file: 108549-21-9.mol

Synonyms:N,N,N',N'-tetrakis(1-Methylethyl)phosphorodiamidous acid phenylmethyl ester

Chemical Property of N,N,N',N'-tetrakis(1-Methylethyl)phosphorodiamidous acid phenylmethyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N,N',N'-tetrakis(1-Methylethyl)phosphorodiamidous acid phenylmethyl ester

There total 12 articles about N,N,N',N'-tetrakis(1-Methylethyl)phosphorodiamidous acid phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzyloxy dichlorophosphine (76101-29-6) + diisopropylamine (108-18-9) → benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite (108549-21-9)

Guidance literature:

In diethyl ether; 1 h, -10 degC, r.t., overnight;

DOI:10.1002/hlca.19870700122

Reference yield: 94.0%

bis(diisopropylamino)chlorophosphine (56183-63-2) + benzyl alcohol (100-51-6,185532-71-2) → benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite (108549-21-9)

Guidance literature:

With triethylamine; In diethyl ether; at 0 ℃;

DOI:10.1021/jm900598m

Reference yield: 56.0%

diisopropylamine (108-18-9) + benzyl alcohol (100-51-6,185532-71-2) → benzyl N,N-diisopropylphosphoramidic acid + Dibenzyl N,N-diisopropylphosphoramidite (108549-23-1) + benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite (108549-21-9)

Guidance literature:

diisopropylamine; With phosphorus trichloride; In hexane; at 0 ℃; Inert atmosphere; Reflux;

benzyl alcohol; With triethylamine; In hexane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1007/s00726-009-0447-0

upstream raw materials:

benzyloxy dichlorophosphine

diisopropylamine

bis(diisopropylamino)chlorophosphine

benzyl alcohol

Downstream raw materials:

1,2-di-O-hexadacanoyl-sn-glycerobenzyl (N,N-diisopropylamino)phopshoramidite

(+)-benzyloxy(N,N-diisopropylamino)(1,2-di-O-hexadecanoyl-sn-glycer-3-yl)phosphine

(S)-2-Benzyloxycarbonylamino-3-(benzyloxy-diisopropylamino-phosphanyloxy)-propionic acid benzyl ester

(2S,3R)-2-Benzyloxycarbonylamino-3-(benzyloxy-diisopropylamino-phosphanyloxy)-butyric acid benzyl ester