N-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]Methyl Lansoprazole Sulfide

Base Information

• Chemical Name: N-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]Methyl Lansoprazole Sulfide
• CAS No.: 1083100-27-9
• Molecular Formula: C₂₅H₂₂F₆N₄O₂S
• Molecular Weight: 556.532
• Mol file: 1083100-27-9.mol

Synonyms:N-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]Methyl Lansoprazole Sulfide;Lansoprazole related substance;1-[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]Methyl]-2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]Methyl]thio]-1H-benziMidazole;Lansoprazole Related Compound 3;Lansoprazole Impurity 1

Chemical Property of N-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]Methyl Lansoprazole Sulfide

Chemical Property:

• Boiling Point: 622.9±65.0 °C(Predicted)
• PKA: 5.25±0.30(Predicted)
• PSA: 87.36000
• Density: 1.39±0.1 g/cm3(Predicted)
• LogP: 6.66590
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

99% ^*data from raw suppliers

N-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylLansoprazoleSulfide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]Methyl Lansoprazole Sulfide

There total 1 articles about N-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]Methyl Lansoprazole Sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3-methyl-4-(2,2,2-trifluoroethoxy)-2-chloromethylpyridine hydrochloride + Benzimidazol-2-thiol (134469-07-1) → 1-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]thio]-1H-benzimidazole (1083100-27-9)

Guidance literature:

With sodium hydroxide; In water; for 4h; Heating;

DOI:10.1080/00397910802162934

Reference yield: 29.5%

1-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]thio]-1H-benzimidazole (1083100-27-9) → 1-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole (1083100-26-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In methanol; chloroform; for 4h;

DOI:10.1080/00397910802162934

upstream raw materials:

Benzimidazol-2-thiol

Downstream raw materials:

1-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole