4-Chloro-6-[2,2,2-trifluoro-1-(3\'-fluoro[1,1\'-biphenyl]-4-yl)ethoxy]-2-pyrimidinamine

Base Information

Chemical Name:4-Chloro-6-[2,2,2-trifluoro-1-(3\'-fluoro[1,1\'-biphenyl]-4-yl)ethoxy]-2-pyrimidinamine
CAS No.:945978-64-3
Molecular Formula:C18H12ClF4N3O
Molecular Weight:397.759
Hs Code.:

$4-Chloro-6-[2,2,2-trifluoro-1-(3\'-fluoro[1,1\'-biphenyl]-4-yl)ethoxy]-2-pyrimidinamine$

Synonyms:4-Chloro-6-[2,2,2-trifluoro-1-(3\'-fluoro[1,1\'-biphenyl]-4-yl)ethoxy]-2-pyrimidinamine

Suppliers and Price of 4-Chloro-6-[2,2,2-trifluoro-1-(3\'-fluoro[1,1\'-biphenyl]-4-yl)ethoxy]-2-pyrimidinamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 4-Chloro-6-[2,2,2-trifluoro-1-(3\'-fluoro[1,1\'-biphenyl]-4-yl)ethoxy]-2-pyrimidinamine

Chemical Property:

PSA：61.76000
LogP:5.13080

Purity/Quality:: 99.0.% ^*data from raw suppliers

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Technology Process of 4-Chloro-6-[2,2,2-trifluoro-1-(3\'-fluoro[1,1\'-biphenyl]-4-yl)ethoxy]-2-pyrimidinamine

There total 6 articles about 4-Chloro-6-[2,2,2-trifluoro-1-(3\'-fluoro[1,1\'-biphenyl]-4-yl)ethoxy]-2-pyrimidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 56-05-3
2-Amino-4,6-dichloropyrimidine

: 945978-63-2
2,2,2-trifluoro-1-(3'-fluoro-[1,1'-biphenyl]-4-yl)ethan-1-ol

: 945978-64-3
4-chloro-6-(2,2,2-trifluoro-1-(3'-fluoro-[1,1'-biphenyl]-4-yl)ethoxy)pyrimidin-2-amine

Guidance literature:: With NaH; In tetrahydrofuran; mineral oil;

Reference yield: 30.0%

: 56-05-3
2-Amino-4,6-dichloropyrimidine

: 2,2,2-trifluoro-1-(3'-fluoro-[1,1'-biphenyl]-4-yl)ethan-1-one

: 945978-64-3
4-chloro-6-(2,2,2-trifluoro-1-(3'-fluoro-[1,1'-biphenyl]-4-yl)ethoxy)pyrimidin-2-amine

Guidance literature:: 2,2,2-trifluoro-1-(3'-fluoro-[1,1'-biphenyl]-4-yl)ethan-1-one; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h;

2-Amino-4,6-dichloropyrimidine; In tetrahydrofuran; at 50 ℃;
DOI:10.1021/acs.orglett.0c01117

Reference yield:

: 4'-bromo-3-fluoro-1,1'-biphenyl

: 945978-64-3
4-chloro-6-(2,2,2-trifluoro-1-(3'-fluoro-[1,1'-biphenyl]-4-yl)ethoxy)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium diacetate; N-Methyldicyclohexylamine; triethylamine; xantphos Pd G₄; tri tert-butylphosphoniumtetrafluoroborate / toluene / 16 h / 80 °C / Inert atmosphere; Sealed tube

2.1: tetramethylammonium fluoride / toluene / 2 h / 20 °C / Inert atmosphere; Sealed tube; Glovebox

2.2: 1 h / 20 °C / Inert atmosphere; Glovebox; Sealed tube

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

3.2: 50 °C

With N-Methyldicyclohexylamine; tetramethylammonium fluoride; palladium diacetate; xantphos Pd G₄; sodium hydride; triethylamine; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; toluene; mineral oil; 1.1: |Weinreb Ketone Synthesis;
DOI:10.1021/acs.orglett.0c01117