2-Fluoro-3-methyl-6-bromophenol

Base Information

• Chemical Name: 2-Fluoro-3-methyl-6-bromophenol
• CAS No.: 1310416-52-4
• Molecular Formula: C7H6BrFO
• Molecular Weight: 205.026
• Mol file: 1310416-52-4.mol

Synonyms:2-Fluoro-3-methyl-6-bromophenol

Chemical Property of 2-Fluoro-3-methyl-6-bromophenol

Chemical Property:

• PSA: 20.23000
• LogP: 2.60220

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

6-bromo-2-fluoro-3-methylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoro-3-methyl-6-bromophenol

There total 2 articles about 2-Fluoro-3-methyl-6-bromophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C9H11BBrFO2 → 6-bromo-2-fluoro-3-methylphenol (1310416-52-4)

Guidance literature:

With dihydrogen peroxide; acetic acid; In water; at 20 ℃;

DOI:10.1021/jm301294g

Reference yield:

2-fluoro-4-bromotoluene (51436-99-8) → 6-bromo-2-fluoro-3-methylphenol (1310416-52-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0 h / -70 - -67 °C

1.2: -70 °C

2.1: dihydrogen peroxide; acetic acid / water / 20 °C

With dihydrogen peroxide; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; water;

DOI:10.1021/jm301294g

Reference yield: 70.0%

potassium 4-(trifluoroboratomethyl)piperazine-1-carboxylic acid tert-butyl ester + 6-bromo-2-fluoro-3-methylphenol (1310416-52-4) → tert-butyl 4-(3-fluoro-2-hydroxy-4-methylbenzyl)piperazine-1-carboxylate

Guidance literature:

With palladium diacetate; caesium carbonate; XPhos; In 1,4-dioxane; water; at 80 ℃; Inert atmosphere;

upstream raw materials:

2-fluoro-4-bromotoluene

Downstream raw materials:

3-(6-bromo-2-fluoro-3-methylphenoxy)-5-chlorobenzonitrile

C₁₈H₁₁BrCl₂FN₅O₂

3-(6-bromo-3-(bromomethyl)-2-fluorophenoxy)-5-chlorobenzonitrile

3-(3-(aminomethyl)-6-bromo-2-fluorophenoxy)-5-chlorobenzonitrile

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