4-Hydroxymethyl-1-methylindazole

Base Information

• Chemical Name: 4-Hydroxymethyl-1-methylindazole
• CAS No.: 1092961-12-0
• Molecular Formula: C₉H₁₀N₂O
• Molecular Weight: 162.191
• Mol file: 1092961-12-0.mol

Synonyms:(1-methyl-1H-indazol-4-yl)methanol;4-(Hydroxymethyl)-1-methyl-1H-indazole

Chemical Property of 4-Hydroxymethyl-1-methylindazole

Chemical Property:

• PSA: 38.05000
• LogP: 1.06560

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Hydroxymethyl-1-methylindazole

There total 1 articles about 4-Hydroxymethyl-1-methylindazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-1H-indazole-4-carbaldehyde (1053655-56-3) → (1-methyl-1H-indazol-4-yl)methanol (1092961-12-0)

Guidance literature:

1-methyl-1H-indazole-4-carbaldehyde; With sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃; for 1h; pH=3; Inert atmosphere;

In tetrahydrofuran; pH=3; Acidic conditions;

Reference yield:

(1-methyl-1H-indazol-4-yl)methanol (1092961-12-0) → 5-methoxy-2-((1-methyl-1H-indazol-4-yl)methoxy)benzaldehyde (1446321-41-0)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 4 h / 20 °C / Inert atmosphere

2: potassium carbonate / acetonitrile / 2 h / Reflux; Inert atmosphere

With thionyl chloride; potassium carbonate; In dichloromethane; acetonitrile;

Reference yield:

(1-methyl-1H-indazol-4-yl)methanol (1092961-12-0) → 4-(chloromethyl)-1-methyl-1H-indazole (1446321-85-2)

Guidance literature:

With thionyl chloride; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

upstream raw materials:

1-methyl-1H-indazole-4-carbaldehyde

Downstream raw materials:

4-(chloromethyl)-1-methyl-1H-indazole

5-methoxy-2-((1-methyl-1H-indazol-4-yl)methoxy)benzaldehyde

Refernces

• 1、 -. "SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION". Paragraph 0159. . Retrieved 2013/07/19.