Pyrrolo[1,2-a]pyrazin-1(2H)-one, hexahydro-3-(hydroxymethyl)-2-methyl-, (3S,8aS)- (9CI)

Base Information

Chemical Name:Pyrrolo[1,2-a]pyrazin-1(2H)-one, hexahydro-3-(hydroxymethyl)-2-methyl-, (3S,8aS)- (9CI)
CAS No.:650578-01-1
Molecular Formula:C₉H₁₆N₂O₂
Molecular Weight:184.238
Hs Code.:
Mol file:650578-01-1.mol

Synonyms:Pyrrolo[1,2-a]pyrazin-1(2H)-one, hexahydro-3-(hydroxymethyl)-2-methyl-, (3S,8aS)- (9CI);(3S,8AS)-3-(HYDROXYMETHYL)-2-METHYLHEXAHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE

Suppliers and Price of Pyrrolo[1,2-a]pyrazin-1(2H)-one, hexahydro-3-(hydroxymethyl)-2-methyl-, (3S,8aS)- (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrrolo[1,2-a]pyrazin-1(2H)-one, hexahydro-3-(hydroxymethyl)-2-methyl-, (3S,8aS)- (9CI)

Chemical Property:

PSA：43.78000
LogP:-0.84050

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Pyrrolo[1,2-a]pyrazin-1(2H)-one, hexahydro-3-(hydroxymethyl)-2-methyl-, (3S,8aS)- (9CI)

There total 5 articles about Pyrrolo[1,2-a]pyrazin-1(2H)-one, hexahydro-3-(hydroxymethyl)-2-methyl-, (3S,8aS)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 650578-00-0
(3S,8aS)-3-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-methylhexahydropyrrolo[1,2-a]pyrazin-1(2H)-one

: 650578-01-1
(3S,8aS)-3-(hydroxymethyl)-2-methylhexahydropyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 650577-98-3
methyl 1-[(2S)-3-hydroxy-2-({[(phenylmethyl)oxy]carbonyl}amino)propyl]-L-prolinate

: 650578-01-1
(3S,8aS)-3-(hydroxymethyl)-2-methylhexahydropyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 5%-palladium/activated carbon; hydrogen / methanol / 1 h / 2068.65 Torr

2.1: triethylamine; dmap / N,N-dimethyl-formamide / 14 h / 20 °C / Cooling with ice

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

3.2: 2.5 h / 0 - 70 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With dmap; 5%-palladium/activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1,2-dideoxy-1-[(2S)-2-(methoxycarbonyl)-1-pyrrolidinyl]-2-[[(phenylmethoxy)carbonyl]amino]-D-glycero-hexitol

: 650578-01-1
(3S,8aS)-3-(hydroxymethyl)-2-methylhexahydropyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium periodate / water / 20 h / 0 °C

1.2: 1 h / 0 °C

2.1: 5%-palladium/activated carbon; hydrogen / methanol / 1 h / 2068.65 Torr

3.1: triethylamine; dmap / N,N-dimethyl-formamide / 14 h / 20 °C / Cooling with ice

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

4.2: 2.5 h / 0 - 70 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With dmap; sodium periodate; 5%-palladium/activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; mineral oil;