5-(6-(3-Methoxyoxetan-3-yl)-4-Morpholinothieno[3,2-d]pyriMidin-2-yl)pyriMidin-2-aMine

Base Information

Chemical Name:5-(6-(3-Methoxyoxetan-3-yl)-4-Morpholinothieno[3,2-d]pyriMidin-2-yl)pyriMidin-2-aMine
CAS No.:1394076-92-6
Molecular Formula:C18H20N6O3S
Molecular Weight:400.4548
Hs Code.:
Mol file:1394076-92-6.mol

Synonyms:5-(6-(3-Methoxyoxetan-3-yl)-4-Morpholinothieno[3,2-d]pyriMidin-2-yl)pyriMidin-2-aMine;GNE-317;5-(6-(3-methoxyoxetan-3-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine

Suppliers and Price of 5-(6-(3-Methoxyoxetan-3-yl)-4-Morpholinothieno[3,2-d]pyriMidin-2-yl)pyriMidin-2-aMine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
GNE-317 >98%
250 mg
$ 900.00

Crysdot
GNE-317 98+%
10mg
$ 105.00

Crysdot
GNE-317 98+%
5mg
$ 61.00

Crysdot
GNE-317 98+%
100mg
$ 364.00

Crysdot
GNE-317 98+%
50mg
$ 294.00

ChemScene
GNE-317 99.31%
100mg
$ 620.00

ChemScene
GNE-317 99.31%
50mg
$ 450.00

ChemScene
GNE-317 99.31%
5mg
$ 95.00

ChemScene
GNE-317 99.31%
10mg
$ 150.00

Axon Medchem
GNE317 98%
2 x 5 mg
$ 143.00

Total 15 raw suppliers

Chemical Property of 5-(6-(3-Methoxyoxetan-3-yl)-4-Morpholinothieno[3,2-d]pyriMidin-2-yl)pyriMidin-2-aMine

Chemical Property:

PSA：136.75000
LogP:2.39360
Storage Temp.:Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Solubility.:Soluble in DMSO

Purity/Quality:

99%, ^*data from raw suppliers

GNE-317 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-(6-(3-Methoxyoxetan-3-yl)-4-Morpholinothieno[3,2-d]pyriMidin-2-yl)pyriMidin-2-aMine

There total 3 articles about 5-(6-(3-Methoxyoxetan-3-yl)-4-Morpholinothieno[3,2-d]pyriMidin-2-yl)pyriMidin-2-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 402960-38-7
5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrimidin-2-ylamine

: 1394077-00-9
4-(2-chloro-6-(3-methoxyoxetan-3-yl)-7-methylthieno[3,2-d]pyrimidin-4-yl)morpholine

: 1394076-92-6
GNE-317

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In acetonitrile; at 140 ℃; for 20h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jm300867c

Reference yield:

: 35265-88-4
4-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)morpholine

: 1394076-92-6
GNE-317

Guidance literature:: Multi-step reaction with 3 steps

1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -48 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / acetonitrile / 20 h / 140 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium hydride; sodium carbonate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; acetonitrile; 3: |Suzuki Coupling;
DOI:10.1021/jm300867c

Reference yield:

: 1394076-99-3
3-(2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)oxetan-3-ol

: 1394076-92-6
GNE-317

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / acetonitrile / 20 h / 140 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; In N,N-dimethyl-formamide; acetonitrile; 2: |Suzuki Coupling;
DOI:10.1021/jm300867c