2,3-Pyridinediamine, N2,N2,4-trimethyl-

Base Information

• Chemical Name: 2,3-Pyridinediamine, N2,N2,4-trimethyl-
• CAS No.: 863128-69-2
• Molecular Formula: C₈H₁₃N₃
• Molecular Weight: 151.211
• Mol file: 863128-69-2.mol

Synonyms:2,3-Pyridinediamine, N2,N2,4-trimethyl-

Chemical Property of 2,3-Pyridinediamine, N2,N2,4-trimethyl-

Chemical Property:

Purity/Quality:

N2,N2,4-trimethyl-2,3-Pyridinediamine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-Pyridinediamine, N2,N2,4-trimethyl-

There total 3 articles about 2,3-Pyridinediamine, N2,N2,4-trimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.23%

2-dimethylamino-4-methyl-3-nitropyridine (21901-20-2) → N,N,4-trimethylpyridine-2,3-diamine (863128-69-2)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 12h;

Reference yield:

2-bromo-3-nitro-4-methyl pyridine (23056-45-3) → N,N,4-trimethylpyridine-2,3-diamine (863128-69-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / tetrahydrofuran; acetonitrile / 6 h / 20 °C

2: trifluoroacetic acid; acetic acid; zinc / 4 h / 0 °C

With sodium hydrogencarbonate; acetic acid; trifluoroacetic acid; zinc; In tetrahydrofuran; acetonitrile;

Reference yield:

2-chloro-3-nitro-4-methylpyridine (23056-39-5) → N,N,4-trimethylpyridine-2,3-diamine (863128-69-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / 0.17 h / 0 °C

1.2: 1 h

2.1: palladium on activated charcoal; hydrogen / methanol / 12 h / 20 °C

With palladium on activated charcoal; hydrogen; sodium hydride; In methanol;

upstream raw materials:

2-bromo-3-nitro-4-methyl pyridine

2-dimethylamino-4-methyl-3-nitropyridine

2-chloro-3-nitro-4-methylpyridine

Refernces

• 1、 -. "KRAS G12C INHIBITORS AND METHODS OF USING THE SAME". . . Retrieved 2019/11/19.