7-Bromo-4,6-dichloroquinazoline

Base Information

• Chemical Name: 7-Bromo-4,6-dichloroquinazoline
• CAS No.: 1260847-61-7
• Molecular Formula: C8H3BrCl2N2
• Molecular Weight: 277.93282
• Hs Code.: 2933990090
• Mol file: 1260847-61-7.mol

Synonyms:7-Bromo-4,6-dichloroquinazoline;7-BroMo-4,6-dichloroquina...

Chemical Property of 7-Bromo-4,6-dichloroquinazoline

Chemical Property:

• Boiling Point: 366.7±37.0 °C(Predicted)
• PKA: 0.11±0.70(Predicted)
• PSA: 25.78000
• Density: 1.851±0.06 g/cm3(Predicted)
• LogP: 3.69910
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Bromo-4,6-dichloroquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Bromo-4,6-dichloroquinazoline

There total 3 articles about 7-Bromo-4,6-dichloroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

7-bromo-6-chloro-3,4-dihydroquinazolin-4-one (17518-98-8) → 7-bromo-4, 6-dichloroquinazoline (1260847-61-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; at 100 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.cclet.2011.01.013

Reference yield:

4-hydroxy-6-chloro-7-bromo-quinazoline (17518-98-8) → 7-bromo-4, 6-dichloroquinazoline (1260847-61-7)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; for 16h; Reflux;

Reference yield:

2-amino-4-bromo-5-chlorobenzoic acid (150812-32-1) → 7-bromo-4, 6-dichloroquinazoline (1260847-61-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium acetate / methanol / 3 h / 120 °C

2: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 1 h / 100 °C / Inert atmosphere

With ammonium acetate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol;

DOI:10.1016/j.cclet.2011.01.013

upstream raw materials:

2-amino-4-bromo-5-chlorobenzoic acid

7-bromo-6-chloro-3,4-dihydroquinazolin-4-one

4-hydroxy-6-chloro-7-bromo-quinazoline

Refernces

• 1、 Li, Ling,Zhao, Huiting,Liao, Hui,Chen, Jingxuan,Liu, Jin,Chen, Jianjun. "Discovery of novel quinazoline-based covalent inhibitors of KRAS G12C with various cysteine-targeting warheads as potential anticancer agents". . . Retrieved 2021.
• 2、 -. "FUSED RING COMPOUNDS". Paragraph 0376. . Retrieved 2020/06/01.