Mannosulfan

Base Information

• Chemical Name: Mannosulfan
• CAS No.: 7518-35-6
• Molecular Formula: C10H22 O14 S4
• Molecular Weight: 494.54
• Mol file: 7518-35-6.mol

Synonyms:Mannitol,1,2,5,6-tetramethanesulfonate (7CI);Mannitol, 1,2,5,6-tetramethanesulfonate,D- (8CI);1,2,5,6-Tetra-O-mesyl-D-mannitol;1,2,5,6-Tetra-O-methylsulfonyl-D-mannitol;1,2,5,6-Tetrakis(methylsulfonyl)-D-mannitol;1,2,5,6-Tetramesyl-D-mannitol;1,2,5,6-Tetramethanesulfonyl-D-mannitol;Mannosulfan;R 52 (antitumoragent);TMSM;Zitostop;

Chemical Property of Mannosulfan

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 114.5°C
• Refractive Index: 1.536
• Boiling Point: 873.8°C at 760 mmHg
• Flash Point: 482.3°C
• PSA: 247.46000
• Density: 1.65g/cm³
• LogP: 0.67340

Purity/Quality:

99%, ^*data from raw suppliers

MANNOSULFAN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,2,5,6-Tetramethanesulfonyl-D-mannitol is a reagent used in the preparation of pharmaceutical compounds for tumor diagnosis and treatment.

Technology Process of Mannosulfan

There total 4 articles about Mannosulfan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methanesulfonic acid (R)-1-[(4S,5S)-5-((R)-1,2-bis-methanesulfonyloxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-methanesulfonyloxy-ethyl ester → 1,2,5,6-Tetrakis-O-(methylsulfonyl)-D-mannitol (7518-35-6)

Guidance literature:

With hydrogenchloride; In methanol; for 4h; Heating;

DOI:10.1016/S0008-6215(00)81159-3

Reference yield:

→ 1,2,5,6-Tetrakis-O-(methylsulfonyl)-D-mannitol (7518-35-6)

Guidance literature:

3,4-O-Isopropyliden-1,2,5,6-tetra-O-(methylsulfonyl)-D-mannit, HCl, MeOH;

Reference yield:

→ 1,2,5,6-Tetrakis-O-(methylsulfonyl)-D-glucitol (7518-35-6,7518-58-3)

Guidance literature:

3,4-O-Isopropyliden-1,2,5,6-tetra-O-(methylsulfonyl)-D-glucit, HCl, MeOH;

Downstream raw materials:

Methanesulfonic acid (1R,2R,3R,4R)-4,5-bis-methanesulfonyloxy-1-methanesulfonyloxymethyl-2,3-bis-sulfooxy-pentyl ester