1H-Pyrrolo[2,3-b]pyridine, 6-chloro-3-(trifluoroMethyl)-

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-3-(trifluoroMethyl)-
• CAS No.: 932406-36-5
• Molecular Formula: C₈H₄ClF₃N₂
• Molecular Weight: 220.581
• Hs Code.: 2933998090
• Mol file: 932406-36-5.mol

Synonyms:1H-Pyrrolo[2,3-b]pyridine, 6-chloro-3-(trifluoroMethyl)-;6-Chloro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-3-(trifluoroMethyl)-

Chemical Property:

• PSA: 28.68000
• LogP: 3.23510
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 95.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-3-(trifluoroMethyl)-

There total 4 articles about 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-3-(trifluoroMethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

6-chloro-3-(trifluoromethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-3-ol (932406-35-4) → 6-chloro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine (932406-36-5)

Guidance literature:

With pyridine; thionyl chloride; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1055/s-2006-958935

Reference yield:

1-(2,6-dichloropyridin-3-yl)-2,2,2-trifluoroethane-1,1-diol (932406-32-1) → 6-chloro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine (932406-36-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 16.4 g / potassium carbonate / tetrahydrofuran / 20 °C

2: 77 percent / H₂ / Raney-nickel / ethanol / 20 °C

3: 82 percent / thionyl chloride; pyridine / CH₂Cl₂ / 2 h / 20 °C

With pyridine; thionyl chloride; hydrogen; nickel; potassium carbonate; In tetrahydrofuran; ethanol; dichloromethane; 1: Henry reaction;

DOI:10.1055/s-2006-958935

Reference yield:

2-(2,6-dichloropyridin-3-yl)-1,1,1-trifluoro-3-nitropropan-2-ol (932406-34-3) → 6-chloro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine (932406-36-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / H₂ / Raney-nickel / ethanol / 20 °C

2: 82 percent / thionyl chloride; pyridine / CH₂Cl₂ / 2 h / 20 °C

With pyridine; thionyl chloride; hydrogen; nickel; In ethanol; dichloromethane;

DOI:10.1055/s-2006-958935

upstream raw materials:

6-chloro-3-(trifluoromethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-3-ol

1-(2,6-dichloropyridin-3-yl)-2,2,2-trifluoroethane-1,1-diol

2-(2,6-dichloropyridin-3-yl)-1,1,1-trifluoro-3-nitropropan-2-ol

2,6-dichloropyridine

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