TELMISARTAN-D3

Base Information

Chemical Name:TELMISARTAN-D3
CAS No.:1189889-44-8
Molecular Formula:C₃₃H₃₀N₄O₂
Molecular Weight:517.603
Hs Code.:

Synonyms:TELMISARTAN-D3;4'-[(1,4'-DiMethyl-2'-propyl[2,6'-bi-H-benziMidazol]-1'-yl)Methyl][1,1'-biphenyl]-2-carboxylic Acid-d3;4'-[[4-Methyl-6-(1-Methyl-2-benziMidazolyl)-2-propyl-1-benziMidazolyl] Methyl]-2-biphenylcarboxylic Acid-d3;BIBR 277-d3;BIBR 277SE-d3;Micardis-d3;Pritor-d3

Suppliers and Price of TELMISARTAN-D3

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Telmisartan-d3
1mg
$ 446.00

TRC
Telmisartan-d3
1mg
$ 175.00

Medical Isotopes, Inc.
Telmisartan-d3
1 mg
$ 390.00

Cayman Chemical
Telmisartan-d3 ≥99% deuterated forms (d1-d3)
1mg
$ 276.00

Cayman Chemical
Telmisartan-d3 ≥99% deuterated forms (d1-d3)
500μg
$ 145.00

American Custom Chemicals Corporation
TELMISARTAN-D3 95.00%
10MG
$ 1732.50

American Custom Chemicals Corporation
TELMISARTAN-D3 95.00%
1MG
$ 721.88

AK Scientific
Telmisartan-d3
1mg
$ 472.00

Total 8 raw suppliers

Chemical Property of TELMISARTAN-D3

Chemical Property:

Melting Point:262-265°C
PSA：72.94000
LogP:7.26440
Storage Temp.:-20?C Freezer, Under Inert Atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

97% ^*data from raw suppliers

Telmisartan-d3 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Telmisartan-d3 is intended for use as an internal standard for the quantification of telmisartan by GC- or LC-MS. Telmisartan is a nonpeptide angiotensin (AT) II receptor antagonist which selectively and insurmountably inhibits the AT II receptor subtype AT1 (Ki = 3.7 nM). It also acts as a partial agonist of peroxisome proliferator-activated receptor gamma (PPARγ), activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (; EC50 = 4.5 μM). Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis.
Uses Labelled Telmisartan, an angiotensin II receptor antagonist TelMisartan-d3 is an angiotensin II receptor antagonist. TelMisartan-d3 can be intended for use as an internal standard for the quantification of Telmisartan by GC- or LC-mass spectrometry.

Technology Process of TELMISARTAN-D3

There total 13 articles about TELMISARTAN-D3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.6%

: C₃₃⁽¹³⁾CH₂₉⁽²⁾H₃N₄O₂

: 1189889-44-8
C₃₂⁽¹³⁾CH₂₇⁽²⁾H₃N₄O₂

Guidance literature:: With water; sodium hydroxide; In methanol; at 20 ℃; for 2h;

Reference yield: 73.0%

: methyl 4-{[2-n-propyl-4-methyl-6-(1-methyl-d₃-benzoimidazol-2-yl)benzoimidazol-1-yl]methyl}biphenyl-2-carboxylate

: 1189889-44-8
4-{[2-n-propyl-4-methyl-6-(1-methyl-d₃-benzoimidazol-2-yl)benzoimidazol-1-yl]methyl}biphenyl-2-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 20 ℃; for 2h;

Reference yield:

: 1-(4-bromobenzyl)-6-(1H-benzo[d]imidazol-2-yl)-4-methyl-2-propyl-1H-benzo[d]imidazole

: 1189889-44-8
C₃₂⁽¹³⁾CH₂₇⁽²⁾H₃N₄O₂

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / acetonitrile / 2 h / -10 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 1.5 h / 100 °C / Inert atmosphere

3: sodium hydroxide; water / methanol / 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium tert-butylate; water; sodium carbonate; sodium hydroxide; In methanol; acetonitrile; 2: |Suzuki Coupling;