3-BrB-PP1

Base Information

Chemical Name:3-BrB-PP1
CAS No.:956025-99-3
Molecular Formula:C₁₆H₁₈BrN₅
Molecular Weight:360.256
Hs Code.:
Mol file:956025-99-3.mol

Synonyms:3-[(3-BroMophenyl)Methyl]-1-(1,1-diMethylethyl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine;3-BrB-PP1;4-AMino-1-tert-butyl-3-(3-broMobenzyl)pyrazolo[3,4-d]pyriMidine

Suppliers and Price of 3-BrB-PP1

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine
10mg
$ 185.00

Medical Isotopes, Inc.
4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine
10 mg
$ 650.00

Total 2 raw suppliers

Chemical Property of 3-BrB-PP1

Chemical Property:

PSA：69.62000
LogP:4.09800
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine is a small molecule Akt inhibitor. The kinase Akt is a key signaling node in regulating cellular growth and survival.

Technology Process of 3-BrB-PP1

There total 6 articles about 3-BrB-PP1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1428640-42-9
C₁₅H₁₇BrN₄

: 77287-34-4,77287-35-5,60100-09-6
formamide

: 956025-99-3
3-(3-bromobenzyl)-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: at 150 ℃;
DOI:10.1039/c6md00675b

Reference yield:

: 1364226-31-2
2-(methoxy-(3-bromobenzyl)methylene)malononitrile

: 956025-99-3
3-(3-bromobenzyl)-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 1 h / Reflux

2: 8 h / 160 - 180 °C

In ethanol;
DOI:10.1021/jm4001314

Reference yield:

: C₁₁H₇BrN₂O

: 956025-99-3
3-(3-bromobenzyl)-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / water; 1,4-dioxane / 1 h / Reflux

2: ethanol / 1 h / Reflux

3: 8 h / 160 - 180 °C

With sodium hydrogencarbonate; In 1,4-dioxane; ethanol; water;
DOI:10.1021/jm4001314