4-(4-(prop-2-ynyloxy)benzoyl)benzoic acid

Base Information

Chemical Name:4-(4-(prop-2-ynyloxy)benzoyl)benzoic acid
CAS No.:1236196-77-2
Molecular Formula:C17H12O4
Molecular Weight:280.28
Hs Code.:
Mol file:1236196-77-2.mol

Synonyms:4-(4-(prop-2-ynyloxy)benzoyl)benzoic acid;4-[4-(2-Propyn-1-yloxy)benzoyl]benzoic Acid

Suppliers and Price of 4-(4-(prop-2-ynyloxy)benzoyl)benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-[4-(2-Propyn-1-yloxy)benzoyl]benzoicAcid
1g
$ 870.00

TRC
4-[4-(2-Propyn-1-yloxy)benzoyl]benzoicAcid
100mg
$ 180.00

Medical Isotopes, Inc.
4-[4-(2-Propyn-1-yloxy)benzoyl]benzoicAcid
2.5 g
$ 2200.00

Total 6 raw suppliers

Chemical Property of 4-(4-(prop-2-ynyloxy)benzoyl)benzoic acid

Chemical Property:

Boiling Point:498.5±40.0 °C(Predicted)
PKA:3.73±0.10(Predicted)
PSA：63.60000
Density:1.269±0.06 g/cm3(Predicted)
LogP:2.62780
Storage Temp.:-20°C
Solubility.:Acetone (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-[4-(2-Propyn-1-yloxy)benzoyl]benzoicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 4-[4-(2-Propyn-1-yloxy)benzoyl]benzoic Acid, is a benzophenone residue used for Protein Photolabeling. It can also be used for the synthesis of new Thiodigalactoside-Based chemical probes to label galectin-3. 4-(4-(Prop-2-yn-1-yloxy)benzoyl)benzoic acid is used for chemical probe synthesis, this trifunctional building block contains a light-activated benzophenone, alkyne tag, and carboxylic acid synthetic handle. When appended to a ligand or pharmacophore through its acid linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Technology Process of 4-(4-(prop-2-ynyloxy)benzoyl)benzoic acid

There total 5 articles about 4-(4-(prop-2-ynyloxy)benzoyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1277177-84-0
C₁₈H₁₄O₄

: 1236196-77-2
propargyloxybenzophenone carboxylic acid

Guidance literature:: With water; lithium hydroxide; In 1,4-dioxane; for 0.5h;
DOI:10.1002/ejoc.201001264

Reference yield:

: 1679-64-7
Monomethyl terephthalate

: 1236196-77-2
propargyloxybenzophenone carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / Reflux

2: aluminum (III) chloride / benzene / 1 h / Reflux

3: sodium hydride / N,N-dimethyl-formamide; toluene; mineral oil / Inert atmosphere

4: water; lithium hydroxide / 1,4-dioxane / 0.5 h

With aluminum (III) chloride; thionyl chloride; water; sodium hydride; lithium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide; toluene; mineral oil; benzene;
DOI:10.1002/ejoc.201001264

Reference yield:

: 71616-84-7
4-methoxycarbonyl-4'-methoxybenzophenone

: 1236196-77-2
propargyloxybenzophenone carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: aluminum (III) chloride / benzene / 1 h / Reflux

2: sodium hydride / N,N-dimethyl-formamide; toluene; mineral oil / Inert atmosphere

3: water; lithium hydroxide / 1,4-dioxane / 0.5 h

With aluminum (III) chloride; water; sodium hydride; lithium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide; toluene; mineral oil; benzene;
DOI:10.1002/ejoc.201001264