4-(2,4-Dichlorophenyl)-1-methyl-1H-pyrrole-3-carboxylic acid

Base Information

Chemical Name:4-(2,4-Dichlorophenyl)-1-methyl-1H-pyrrole-3-carboxylic acid
CAS No.:191668-29-8
Molecular Formula:C12H9Cl2NO2
Molecular Weight:0
Hs Code.:
DSSTox Substance ID:DTXSID00702315
Wikidata:Q82634192
Mol file:191668-29-8.mol

Synonyms:191668-29-8;DTXSID00702315;XYEKBXGFQMGDIP-UHFFFAOYSA-N;4-(2,4-DICHLOROPHENYL)-1-METHYL-1H-PYRROLE-3-CARBOXYLIC ACID

Suppliers and Price of 4-(2,4-Dichlorophenyl)-1-methyl-1H-pyrrole-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 4-(2,4-Dichlorophenyl)-1-methyl-1H-pyrrole-3-carboxylic acid

Chemical Property:

PSA：42.23000
LogP:3.69710
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:269.0010339
Heavy Atom Count:17
Complexity:300

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C=C(C(=C1)C(=O)O)C2=C(C=C(C=C2)Cl)Cl

Technology Process of 4-(2,4-Dichlorophenyl)-1-methyl-1H-pyrrole-3-carboxylic acid

There total 3 articles about 4-(2,4-Dichlorophenyl)-1-methyl-1H-pyrrole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 191668-16-3
4-(2,4-dichloro-phenyl)-1-methyl-1H-pyrrole-3-carboxylic acid ethyl ester

: 191668-29-8
4-(2,4-dichloro-phenyl)-1-methyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 5h; Heating;

Reference yield:

: 1504-68-3,24393-62-2
(E)-ethyl 3-(2,4-dichlorophenyl)acrylate

: 191668-29-8
4-(2,4-dichloro-phenyl)-1-methyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / 60 percent sodium hydride in oil / dimethylsulfoxide; diethyl ether / 0.08 h / 20 °C

2: 99 percent / potassium carbonate / dimethylformamide / 18 h / 90 °C

3: 100 percent / aq. sodium hydroxide / aq. ethanol / 5 h / Heating

With sodium hydroxide; sodium hydride; potassium carbonate; In diethyl ether; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Cycloaddition / 2: Methylation / 3: Hydrolysis;

Reference yield:

: 191668-09-4
4-(2,4-Dichloro-phenyl)-1H-pyrrole-3-carboxylic acid ethyl ester

: 191668-29-8
4-(2,4-dichloro-phenyl)-1-methyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / potassium carbonate / dimethylformamide / 18 h / 90 °C

2: 100 percent / aq. sodium hydroxide / aq. ethanol / 5 h / Heating

With sodium hydroxide; potassium carbonate; In ethanol; N,N-dimethyl-formamide; 1: Methylation / 2: Hydrolysis;