3-(4-AMINONAPHTHALEN-1-YL)-N-BOC-L-ALANINE

Base Information

• Chemical Name: 3-(4-AMINONAPHTHALEN-1-YL)-N-BOC-L-ALANINE
• CAS No.: 436864-62-9
• Molecular Formula: C18H22N2O4
• Molecular Weight: 330.37828
• Hs Code.: 2924299090
• Mol file: 436864-62-9.mol

Synonyms:3-(4-AMINONAPHTHALEN-1-YL)-N-BOC-L-ALANINE ;(S)-3-(4-Amino-naphthalen-1-yl)-2-tert-butoxycarbonylamino-propionic acid

Chemical Property of 3-(4-AMINONAPHTHALEN-1-YL)-N-BOC-L-ALANINE

Chemical Property:

• Vapor Pressure: 1.84E-13mmHg at 25°C
• Boiling Point: 561.9°C at 760 mmHg
• Flash Point: 293.6°C
• PSA: 101.65000
• Density: 1.246g/cm³
• LogP: 3.91450

Purity/Quality:

97% ^*data from raw suppliers

(S)-3-(4-AMINO-NAPHTHALEN-1-YL)-2-TERT-BUTOXYCARBONYLAMINO-PROPIONIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-AMINONAPHTHALEN-1-YL)-N-BOC-L-ALANINE

There total 3 articles about 3-(4-AMINONAPHTHALEN-1-YL)-N-BOC-L-ALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

S-3-(4-aminonaphthalen-1-yl)-2-(tert-butoxycarbonylamino)propionic acid methyl ester (436864-61-8) → S-3-(4-aminonaphthalen-1-yl)-2-(tert-butoxycarbonylamino)propionic acid (436864-62-9,1212819-92-5)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 2.5h;

DOI:10.1021/ja0296733

Reference yield:

4-Bromo-1-naphthylamine (2298-07-9) → S-3-(4-aminonaphthalen-1-yl)-2-(tert-butoxycarbonylamino)propionic acid (436864-62-9,1212819-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Zn / dimethylformamide / 0.25 h / 65 °C

1.2: 46 percent / Pd(OAc)2; tris(o-tolyl)phosphine / dimethylformamide / 1.5 h / 65 °C

2.1: 91 percent / aq. NaOH / methanol / 2.5 h / 20 °C

With sodium hydroxide; zinc; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/ja0296733

Reference yield:

N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester (93267-04-0,170848-34-7,889670-02-4) → S-3-(4-aminonaphthalen-1-yl)-2-(tert-butoxycarbonylamino)propionic acid (436864-62-9,1212819-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Zn / dimethylformamide / 0.25 h / 65 °C

1.2: 46 percent / Pd(OAc)2; tris(o-tolyl)phosphine / dimethylformamide / 1.5 h / 65 °C

2.1: 91 percent / aq. NaOH / methanol / 2.5 h / 20 °C

With sodium hydroxide; zinc; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/ja0296733

upstream raw materials:

S-3-(4-aminonaphthalen-1-yl)-2-(tert-butoxycarbonylamino)propionic acid methyl ester

4-Bromo-1-naphthylamine

N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester

Downstream raw materials:

(S)-3-{{5-[[2-(tert-butoxycarbonylamino)-3-[4-((2-carboxyphenyl)amino)naphthalen-1-yl]propionyl]amino]pentyl}oxy}naphthalene-2-carboxylic acid

3-[5-(2-tert-butoxycarbonylamino-3-{4-[(2-carboxy-phenyl)-hydroxyoxalyl-amino]-naphthalen-1-yl}-propionylamino)-pentyloxy]-naphthalene-2-carboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 436864-62-9 3-(4-AMINONAPHTHALEN-1-YL)-N-BOC-L-ALANINE

Send

Send

Metric Ton KG G Pound L ML

Send

Send