(4R)-4-(dipropylamino)-1,3,4,5-tetrahydrobenzo[cd]indole-6-carboxamide

Base Information

Chemical Name:(4R)-4-(dipropylamino)-1,3,4,5-tetrahydrobenzo[cd]indole-6-carboxamide
CAS No.:115994-31-5
Molecular Formula:C₁₈H₂₅N₃O
Molecular Weight:299.416
Hs Code.:

Synonyms:Benz[cd]indole-6-carboxamide,4-(dipropylamino)-1,3,4,5-tetrahydro-, (R)-; LY 228729

Suppliers and Price of (4R)-4-(dipropylamino)-1,3,4,5-tetrahydrobenzo[cd]indole-6-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R)-4-(dipropylamino)-1,3,4,5-tetrahydrobenzo[cd]indole-6-carboxamide

Chemical Property:

Vapor Pressure:1.6E-10mmHg at 25°C
Boiling Point:510.1°Cat760mmHg
Flash Point:262.3°C
Density:1.17g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (4R)-4-(dipropylamino)-1,3,4,5-tetrahydrobenzo[cd]indole-6-carboxamide

There total 24 articles about (4R)-4-(dipropylamino)-1,3,4,5-tetrahydrobenzo[cd]indole-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 136791-11-2
(2aR,4S)-4-Dipropylamino-1,2,2a,3,4,5-hexahydro-benzo[cd]indole-6-carboxylic acid amide

: 115994-31-5,100561-24-8
LY 228729

Guidance literature:: palladium on activated charcoal; In methanol; sulfuric acid; water; at 80 ℃; for 7h;
DOI:10.1021/jo971256z

Reference yield: 25.0%

: 1118-02-1
trimethylsilyl isocyanate

: (6-bromo-1,3,4,5-tetrahydro-benzo[cd]indol-4-yl)-dipropyl-amine

: 115994-31-5,100561-24-8
LY 228729

Guidance literature:: (6-bromo-1,3,4,5-tetrahydro-benzo[cd]indol-4-yl)-dipropyl-amine; With tert.-butyl lithium; potassium hydride; In diethyl ether; pentane; at -78 - -40 ℃;

trimethylsilyl isocyanate; In diethyl ether; pentane; at -78 - -10 ℃;
DOI:10.1002/jlcr.907

Reference yield:

: 39890-59-0,124578-75-2,124578-76-3
Phenyl-(5aS,6aS,7aR)-5a,6,6a,7a-tetrahydro-5H-7-oxa-4-aza-cyclopropa[e]acenaphthylen-4-yl-methanone

: 115994-31-5,100561-24-8
LY 228729

Guidance literature:: Multi-step reaction with 9 steps

1: 43 percent / butan-1-ol / 24 h / 90 °C

2: 84.5 percent / PPh₃, DEAD / tetrahydrofuran / Ambient temperature

3: 71 percent / H₂, phosphoric acid, KOH / Pd/C / H₂O; tetrahydrofuran / 6 h / 0 - 55 °C / 760 Torr

4: 88.8 percent / Br₂, NaOAc / acetic acid / Ambient temperature

5: 80 percent / K₂CO₃ / acetonitrile / 75 °C

6: 75.7 percent / various solvent(s) / 2.5 h / 200 °C

7: 94.5 percent / n-BuLi / tetrahydrofuran / -65 °C

8: 23.53 g / PPA / 2 h / 85 - 90 °C

9: 62 percent / MnO₂ / CH₂Cl₂; acetic acid / 5.5 h / -10 °C / other reagent, solvent, temperature, reaction time

With manganese(IV) oxide; potassium hydroxide; n-butyllithium; phosphoric acid; hydrogen; bromine; sodium acetate; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; acetic acid; acetonitrile; butan-1-ol;
DOI:10.1021/jo971256z