3-(trifluoroMethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine hydrochloride

Base Information

• Chemical Name: 3-(trifluoroMethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine hydrochloride
• CAS No.: 1158357-67-5
• Molecular Formula: C8H8ClF3N2
• Molecular Weight: 224.6107296
• Hs Code.: 2933990090
• Mol file: 1158357-67-5.mol

Synonyms:3-(trifluoroMethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine hydrochloride;3-(trifluoromethyl)-5H,6H,7H-pyrrolo[3,4-b]pyridine hydrochloride

Chemical Property of 3-(trifluoroMethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine hydrochloride

Chemical Property:

• PSA: 24.92000
• LogP: 2.83440
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

3-(Trifluoromethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridinehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(trifluoroMethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine hydrochloride

There total 1 articles about 3-(trifluoroMethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.7%

6-benzhydryl-3-trifluoromethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine hydrochloride salt (1158357-50-6) → 3-trifluoromethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-6-ium chloride (1158357-67-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 - 25 ℃; for 3 - 4h; under 1125.11 Torr;

Reference yield:

5-methane-sulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid (845616-82-2,845616-83-3) + 3-trifluoromethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-6-ium chloride (1158357-67-5) → [5-methylsulfonyl-2-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]phenyl]-[3-(trifluoromethyl)-5,7-dihydropyrrolo[3,4-b]pyridin-6-yl]methanone

Guidance literature:

5-methane-sulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In toluene; at 20 ℃; for 1.23333h;

3-trifluoromethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-6-ium chloride; With triethylamine; In toluene; at 20 ℃; for 2.76667h; Product distribution / selectivity;

upstream raw materials:

6-benzhydryl-3-trifluoromethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine hydrochloride salt

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