3-(2-CHLOROPHENYL)-5-METHYLISOOXAZOLE

Base Information

• Chemical Name: 3-(2-CHLOROPHENYL)-5-METHYLISOOXAZOLE
• CAS No.: 916791-93-0
• Molecular Formula: C10H8ClNO
• Molecular Weight: 193.633
• Mol file: 916791-93-0.mol

Synonyms:3-(2-CHLOROPHENYL)-5-METHYLISOOXAZOLE

Chemical Property of 3-(2-CHLOROPHENYL)-5-METHYLISOOXAZOLE

Chemical Property:

• PSA: 26.03000
• LogP: 3.30340

Purity/Quality:

98%min ^*data from raw suppliers

3 -(2-CHLOROPHENYL)-5-METHYLISOXAZOLE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-CHLOROPHENYL)-5-METHYLISOOXAZOLE

There total 4 articles about 3-(2-CHLOROPHENYL)-5-METHYLISOOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-(2-chlorophenyl)but-3-en-1-one oxime (1574316-74-7) → 3-(2-chlorophenyl)-5-methylisooxazole (916791-93-0)

Guidance literature:

With palladium diacetate; silver carbonate; In chlorobenzene; at 70 ℃; for 8h;

DOI:10.1021/ol502246t

Reference yield:

1-(2-chloro phenyl) but-3-en-1-one → 3-(2-chlorophenyl)-5-methylisooxazole (916791-93-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium acetate / water; ethanol / 20 °C

2: palladium diacetate; silver carbonate / chlorobenzene / 8 h / 70 °C

With hydroxylamine hydrochloride; sodium acetate; palladium diacetate; silver carbonate; In ethanol; water; chlorobenzene;

DOI:10.1021/ol502246t

Reference yield:

2-chloro-benzaldehyde (89-98-5) → 3-(2-chlorophenyl)-5-methylisooxazole (916791-93-0)

Guidance literature:

Multi-step reaction with 4 steps

1: diethyl ether / 0 - 20 °C

2: Jones reagent / diethyl ether / 1 h / 0 - 20 °C

3: hydroxylamine hydrochloride; sodium acetate / water; ethanol / 20 °C

4: palladium diacetate; silver carbonate / chlorobenzene / 8 h / 70 °C

With Jones reagent; hydroxylamine hydrochloride; sodium acetate; palladium diacetate; silver carbonate; In diethyl ether; ethanol; water; chlorobenzene;

DOI:10.1021/ol502246t

upstream raw materials:

1-(2-chlorophenyl)but-3-en-1-one oxime

2-chloro-benzaldehyde

1-(2-chlorophenyl)but-3-en-1-ol

Refernces