2-CHLORO-7-FLUOROBENZOTHIAZOLE

Base Information

• Chemical Name: 2-CHLORO-7-FLUOROBENZOTHIAZOLE
• CAS No.: 154327-28-3
• Molecular Formula: C7H3ClFNS
• Molecular Weight: 187.62
• Hs Code.: 2934200090
• Mol file: 154327-28-3.mol

Synonyms:2-CHLORO-7-FLUOROBENZOTHIAZOLE;2-Chloro-7-fluorobenzo[d]thiazole;Benzothiazole, 2-chloro-7-fluoro-

Chemical Property of 2-CHLORO-7-FLUOROBENZOTHIAZOLE

Chemical Property:

• Boiling Point: 253.0±13.0 °C(Predicted)
• PKA: -1.07±0.30(Predicted)
• PSA: 41.13000
• Density: 1.532±0.06 g/cm3(Predicted)
• LogP: 3.08880
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-chloro-7-fluorobenzo[d]thiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-7-FLUOROBENZOTHIAZOLE

There total 4 articles about 2-CHLORO-7-FLUOROBENZOTHIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-mercapto-7-fluorobenzothiazole (154327-29-4) → 2-chloro-7-fluoro-1,3-benzothiazole (154327-28-3)

Guidance literature:

7-fluoro-2-mercaptobenzothiazole; With sulfuryl dichloride; at 20 - 25 ℃; for 0.25h; Inert atmosphere;

With water; at 20 - 25 ℃; for 3h; Inert atmosphere;

DOI:10.1055/s-0036-1591553

Reference yield:

2,3-difluoroanilline (4519-40-8) → 2-chloro-7-fluoro-1,3-benzothiazole (154327-28-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / dimethylformamide / 2 h / 120 °C

2: 59 percent / SO₂Cl₂ / 2 h / 20 °C

With sulfuryl dichloride; In N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570420440

Reference yield:

2,3-difluoroanilline (4519-40-8) + potassium ethyl xanthogenate (140-89-6) → 2-chloro-7-fluoro-1,3-benzothiazole (154327-28-3)

Guidance literature:

2,3-difluoroanilline; potassium ethyl xanthogenate; In N,N-dimethyl-formamide; Inert atmosphere;

With sulfuryl dichloride; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b01996 DOI:10.1021/acs.jmedchem.8b01996

upstream raw materials:

2-mercapto-7-fluorobenzothiazole

2,3-difluoroanilline

potassium ethyl xanthogenate

Refernces

• 1、 -. "Small-compound enhancers for functional O-mannosylation of alpha-dystroglycan, and uses thereof". Page/Page column 24. . Retrieved 2019/03/14.
• 2、 Chen, Ge,Niu, Chunyi,Yi, Jianhua,Sun, Lin,Cao, Hengyi,Fang, Yanjia,Jin, Taijie,Li, Ying,Lou, Chunli,Kang, Jingwu,Wei, Wanguo,Zhu, Jidong. "Novel Triapine Derivative Induces Copper-Dependent Cell Death in Hematopoietic Cancers". . . Retrieved 2019/04/01.